COBRE: UND: CARBONYL DETOXIFICATION IN CNS

COBRE：UND：中枢神经系统中的羰基解毒

• 批准号: 7171126
• 负责人: MATTHEW J PICKLO
• 金额: $ 18.82万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171126
• 关键词: clinical research; neural degeneration; neurosciences; pathologic process

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence (COBRE) on the Pathophysiology of neurodegenerative diseases at the University of North Dakota. The overall objective of this Center is to characterize the cellular mechanisms that contribute to neuronal degeneration. The proposed Center will consist of five projects involving 6 junior faculty members, each of which examines a unique aspect of the neurodegenerative process. These five projects, together with the proposed core facilities, faculty recruitments and administrative core will greatly assist us in meeting our long term goal: To develop a highly interactive and collaborative research group focused on understanding the etiology of neurodegeneration and developing therapeutic approaches to prevent or halt neuropathology. The Specific Aims of this COBRE are: 1.) To develop successful independent research projects for the COBRE project directors that will enable them to obtain extramural R01 research grants. 2.) To enhance research infrastructure at the University of North Dakota School of Medicine & Health Sciences (UNDSMHS) through the development of core facilities to support all investigators. 3.) To expand biomedical faculty research in the area of neuroscience through the recruitment of an established senior level neuroscientist and four junior faculty members to UNDSMHS whose research is in the theme of our COBRE. These new faculty recruits will establish a critical mass of researchers at UNDSMHS whose areas of research expertise are in complimentary areas of neuroscience. 4.) To establish a nationally and internationally recognized Center of Neuroscience Research Excellence at the University of North Dakota. The successful completion of COBRE Specific Aims will establish a reputation at UNDSMHS as a Center of Neuroscience Research Excellence that will attract faculty, postdoctoral fellows, and graduate students interested in neuroscience research. Our Center will then be highly competitive for obtaining training grants, program project grants and center grants that will allow for the continuation of the Center of Neuroscience Research Excellence beyond the COBRE award.

描述（由申请人提供）：本提案旨在建立北达科他州大学神经退行性疾病病理生理学生物医学研究卓越中心（COBRE）。本中心的总体目标是描述导致神经元变性的细胞机制。该中心将由5个项目组成，涉及6名初级教员，每个项目都研究神经退行性过程的一个独特方面。这五个项目，连同拟议的核心设施，教师招聘和行政核心，将极大地帮助我们实现我们的长期目标：建立一个高度互动和合作的研究小组，专注于了解神经变性的病因，并开发预防或停止神经病理学的治疗方法。本COBRE的具体目标是：1)为COBRE项目主管开发成功的独立研究项目，使他们能够获得校外R01研究资助。2.） 通过发展支持所有研究人员的核心设施，加强北达科他州大学医学与健康科学学院的研究基础设施。3.） 通过招聘一名资深神经科学家和四名初级教员，扩大生物医学教员在神经科学领域的研究，他们的研究与我们的COBRE的主题一致。这些新征聘的教员将在卫生和管理委员会建立一个临界数量的研究人员，他们的研究专长领域是神经科学的补充领域。4.） 在北达科他大学建立一个国内和国际公认的神经科学研究卓越中心。COBRE具体目标的成功完成将在unsmhs建立作为神经科学卓越研究中心的声誉，这将吸引对神经科学研究感兴趣的教师，博士后研究员和研究生。然后，我们的中心将在获得培训补助金、项目补助金和中心补助金方面进行激烈的竞争，这些补助金将允许神经科学研究卓越中心在COBRE奖之外继续发展。