COBRE: UMMC: NEURONAL MECHANISMS UNDERLYING OPIOID ADDICTION

COBRE：UMMC：阿片类药物成瘾的神经机制

• 批准号: 7171144
• 负责人: HONG ZHU
• 金额: $ 3.43万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171144
• 关键词: clinical research; education evaluation /planning; health science research potential; health science research support; neuropsychology; neurosciences; psychopharmacology; training

DESCRIPTION (provided by applicant): Psychiatric neuroscience is an exciting and burgeoning field that has contributed to many recent major discoveries regarding the relationship between neurobiology and behavior. An enhanced commitment to this research in the next decade holds the promise of major advances in the diagnosis and treatment of psychiatric illnesses such as depression, schizophrenia, and substance abuse disorders. The University of Mississippi Medical Center (UMMC) has made a major commitment to this field of medicine over the past 8 years by the recruitment of a number of prominent scientists and clinicians engaged in psychiatric neuroscience research. UMMC proposes to build on this existing strength by establishing the Center for Research Excellence in Psychiatric Neuroscience (CREPN). The CREPN will create and maintain a quality research environment highly conducive to productive and clinically-oriented basic research in the psychiatric neurosciences. A major goal of CREPN will be to nurture the transition of junior faculty neuroscientists to independent researchers through a multi-disciplinary program of cutting-edge psychiatric neuroscience research. The CREPN will foster a diverse and nationally competitive environment that will facilitate research careers of junior faculty and will foster collaborations between psychiatric neuroscientists at UMMC and throughout Mississippi. These goals will be achieved by establishing formal mentoring relationships between junior psychiatric neuroscientists and senior faculty with established records in NIH-funded psychiatric neuroscience research. The CREPN will enhance the methodological sophistication of junior investigators by providing access to state-of-the-art core facilities including a core facility for behavioral studies, a cellular neuroimaging facility, an interactive web-based psychiatric neuroscience resource, and a collection of psychiatrically-characterized post-mortem brains. In addition, a neuroscientist that utilizes predominantly molecular biological approaches to psychiatric neuroscience research will be recruited to the Center. Overall, the establishment of the CREPN will enrich and diversify the academic environment in Mississippi for junior investigators in psychiatric neuroscience and thereby enhance their ability to compete nationally through traditional granting mechanisms.

描述（由申请人提供）：精神病学神经科学是一个令人兴奋的和新兴的领域，有助于许多最近的重大发现，关于神经生物学和行为之间的关系。在未来十年内加强对这项研究的承诺，有望在抑郁症、精神分裂症和药物滥用障碍等精神疾病的诊断和治疗方面取得重大进展。密西西比大学医学中心（UMMC）在过去的8年里，通过招募一些从事精神神经科学研究的杰出科学家和临床医生，对这一医学领域做出了重大承诺。UMMC建议通过建立精神病学神经科学卓越研究中心（CREPN）来建立现有的优势。CREPN将创造和保持一个高质量的研究环境，非常有利于精神神经科学的生产和临床导向的基础研究。CREPN的一个主要目标是通过一个多学科的尖端精神神经科学研究项目，培养初级神经科学家向独立研究人员的过渡。CREPN将促进多样化和全国竞争的环境，这将促进初级教师的研究生涯，并将促进UMMC和整个密西西比的精神神经科学家之间的合作。这些目标将通过在初级精神神经科学家和具有NIH资助的精神神经科学研究记录的高级教师之间建立正式的指导关系来实现。CREPN将通过提供最先进的核心设施，包括行为研究的核心设施，细胞神经成像设施，基于网络的交互式精神神经科学资源，以及精神病学特征的死后大脑的集合，来提高初级研究人员的方法复杂性。此外，一名主要利用分子生物学方法进行精神神经科学研究的神经科学家将被招募到该中心。总的来说，CREPN的建立将丰富和多样化的学术环境在密西西比的初级研究人员在精神神经科学，从而提高他们的能力，通过传统的授予机制在全国范围内竞争。