DE PEDIATRIC COBRE: MOLECULAR MECHANISMS IN PELIZAEUS MERZBACHER DISEASE

DE PEDIATRIC COBRE：Pelizaeus Merzbacher 病的分子机制

• 批准号: 7171397
• 负责人: Grace M. Hobson
• 金额: $ 14.88万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171397
• 关键词: clinical research; human subject; pediatrics

DESCRIPTION (provided by applicant): The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of Delaware. This will be accomplished through the efforts of a multidisciplinary group of investigators at the Nemours Research Institute/Alfred I. duPont Hospital for Children, to study pediatric diseases, therapy and prevention. The Nemours Research Institute is located on the grounds of the Alfred I. duPont Hospital in Wilmington, Delaware, where a close relationship is maintained between the two facilities. The new research center, The Center for Pediatric Research (CPR), will focus on three aims: 1) To develop a Center that will support basic and applied research on pediatric disorders by providing the infrastructure to train basic and physician scientists (target investigators) in their quest to become independent investigators who can successfully procure outside funding for their research programs. The CPR will foster the development of these junior scientists by providing the money, resources and core lab services for the projects; 2) To develop an integrated mentoring program to enrich the training of the target investigators. Established investigators with proven histories in scientific research and grant acquisition will provide scientific and academic direction to the target investigators, thus fostering the advancement of this core group of scientists to build a stronger research program, ensuring the long-term expansion of biomedical research in Delaware; and 3) To develop a translational research program within the CPR that enriches the interface between clinical and basic research by developing clinically relevant systems for basic research as well as scientifically sound approaches to clinical research. We will recruit investigators with experience in clinical and applied basic research to form a multidisciplinary research group studying pediatric diseases, providing additional research programs and infrastructure for the long-term development of an NIH-funded Translational CPR at the Nemours Research Institute. The COBRE program proposed herein wilt have two long-term benefits: 1) the number of NIH-competitive researchers in Delaware will increase; 2) the CPR will be poised to apply for a other Center grants which are few in Delaware.

描述（由申请人提供）： 这项COBRE提案的主要目标是增加特拉华州由NIH资助的活跃生物医学研究人员的数量。这将通过内穆尔研究所/阿尔弗雷德一世的一个多学科研究小组的努力来完成。杜邦儿童医院，研究儿科疾病，治疗和预防。内穆尔研究所位于阿尔弗雷德一世的场地上。位于特拉华州威尔明顿的杜邦医院，两个机构之间保持着密切的关系。新的研究中心，儿科研究中心（CPR），将专注于三个目标：1）开发一个中心，将通过提供基础设施来支持儿科疾病的基础和应用研究，以培训基础和医生科学家（目标研究者），使他们成为独立的研究者，他们可以成功地为他们的研究项目获得外部资金。CPR将通过为项目提供资金、资源和核心实验室服务来促进这些初级科学家的发展; 2）制定综合指导计划，以丰富目标研究者的培训。在科学研究和赠款获得方面具有成熟历史的既定研究者将为目标研究者提供科学和学术方向，从而促进这一核心科学家群体的发展，以建立更强大的研究计划，确保特拉华州生物医学研究的长期扩展;和3）在CPR内开发一个转化研究计划，通过开发临床相关的基础研究系统，丰富临床和基础研究之间的接口作为临床研究的科学方法。我们将招募具有临床和应用基础研究经验的研究人员，组成一个研究儿科疾病的多学科研究小组，为Nemours研究所的NIH资助的翻译CPR的长期发展提供额外的研究计划和基础设施。本文提出的COBRE计划将有两个长期的好处：1）在特拉华州的NIH竞争力的研究人员的数量将增加; 2）CPR将准备申请其他中心的赠款，这是很少在特拉华州。