COBRE: U KS: P1: ID OF HSP90 COCHAPERONES, IMMUNOPHILINS & PROTEINS

COBRE：UK KS：P1：HSP90 辅助伴侣、免疫亲和素的 ID

• 批准号: 7171176
• 负责人: Brian S J Blagg
• 金额: $ 16.5万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171176
• 关键词: clinical research; health science research potential; protein structure function; structural biology

DESCRIPTION (provided by applicant): Five years of support are requested to establish a program for development of junior faculty with research interests in Protein Structure and Function, with the goal of enabling them to become fully competitive for NIH grant support. Four Ph.D.-granting institutions in Kansas are participating, including KU-Lawrence, K-State University, KU-School of Medicine, and Wichita State University. The Principal Investigator, co-investigator, and a strong group of established, NIH-funded faculty, along with outstanding scientists on an External Advisory Committee (EAC), will provide mentoring and assistance to new faculty, not only in establishing highly competitive research programs in the study of protein structure and function but in their overall development as academic scientists. Individual mentoring plans with specific milestones form the basis for the development program. This will be supplemented with a seminar series by prominent scientists alternating with research presentations by COBRE investigators and workshops dealing with technical aspects of protein analysis, publishing, grant writing, and lab management. One administrative and two scientific Cores will be established to administer the program and provide high caliber technical expertise and instrumentation. Protein Structure and Function was selected as a theme because (1) detailed understanding of proteins is the next great challenge in overcoming diseases, (2) a strong cadre of senior faculty in Kansas are working in this area, and (3) current and future hiring plans for new faculty throughout the State of Kansas emphasize studies in protein structure and function. This focus on multi-disciplinary research on proteins enables us to capitalize on recent University investments in research infrastructure, and to obtain substantial institutional support for the proposed program in the form of FTEs, new research instrumentation, and space. Six faculty have been selected for 2-3 years of support, based on scientific merit, relevance for the COBRE theme, potential to benefit from the mentoring program and the Core labs, and likelihood of developing their project to compete successfully for NIH grants in the future. Progress toward the goals of the Program will be monitored by self-study and by Internal and External Advisory Committees; the latter will also review proposals and applications from new junior faculty for COBRE support.

描述（由申请人提供）：要求五年的支持，以建立一个计划，用于发展初级教师与蛋白质结构和功能的研究兴趣，使他们能够成为NIH资助支持充分竞争的目标。四个博士学位-堪萨斯州的授权机构正在参与，包括KU-Lawrence，K-State University，KU-School of Medicine和威奇托州立大学。主要研究者，共同研究者，和一个强大的团队建立，NIH资助的教师，沿着与外部咨询委员会（EAC）的杰出科学家，将提供指导和帮助新的教师，不仅在建立蛋白质结构和功能的研究，但在他们的整体发展作为学术科学家的高度竞争力的研究项目。具有特定里程碑的个人指导计划构成了发展计划的基础。这将与著名科学家的系列研讨会相补充，由COBRE研究人员和研讨会交替进行研究报告，涉及蛋白质分析，出版，资助写作和实验室管理的技术方面。将建立一个行政核心和两个科学核心来管理该计划，并提供高素质的技术专长和仪器。蛋白质的结构和功能被选为主题，因为（1）详细了解蛋白质是下一个巨大的挑战，在克服疾病，（2）在堪萨斯高级教师的强大干部正在这一领域的工作，和（3）当前和未来的招聘计划，新的教师在整个堪萨斯强调蛋白质结构和功能的研究。这种对蛋白质多学科研究的关注使我们能够利用最近大学对研究基础设施的投资，并以全职员工，新的研究仪器和空间的形式为拟议的计划获得大量的机构支持。根据科学价值，COBRE主题的相关性，从指导计划和核心实验室中受益的潜力，以及开发他们的项目以成功竞争NIH赠款的可能性，选择了六名教师进行2-3年的支持。实现该计划的目标的进展情况将通过自学和内部和外部咨询委员会进行监测;后者还将审查新的初级教师对COBRE支持的建议和申请。