UHI COBRE: P2: IMMUNOPATHOGENESIS OF DENGUE VIRUS INFECTION

描述（由申请人提供）： 为了应对该区域传染病的重新抬头，并根据建立亚太热带医学和传染病研究所的高度优先机构倡议，本申请提议在夏威夷大学马诺阿分校建立太平洋新发传染病研究中心。通过利用约翰A。伯恩斯医学院，太平洋生物医学研究中心，夏威夷癌症研究中心，以及夏威夷州卫生部，新中心将锚定的原则，跨学科研究。各项目将通过统一的研究重点联系起来，研究传染病的分子流行病学和发病机制，这些疾病具有地方和区域相关性，对夏威夷和亚太地区服务不足的少数民族社区产生了不成比例的影响。具体而言，将对异性恋男性中人乳头瘤病毒感染的自然史、登革热的免疫发病机制以及与夏威夷高发病率急性风湿热有关的A组链球菌的分子流行病学和粘附特性进行研究。从这些研究项目中获得的新知识将为预防和控制这些区域性重要传染病提供更好的战略。拟建中心的总体目标将通过以下具体目标实现： 1.通过指导一批有前途的年轻教员进行对亚太区域具有重要医学意义的传染病研究，建设机构能力。 2.通过加强指导能力和扩大技术支持基础设施的能力，提高研究竞争力。 3.多样化的研究广度和中心的跨学科范围，通过有针对性的招聘和保留资助的教师与互补的专业知识，并通过实验室空间和研究支持业务的集中化。

DESCRIPTION (provided by applicant): In response to a regional resurgence of infectious diseases and consistent with a high-priority institutional initiative to establish the Asia-Pacific Institute for Tropical Medicine and Infectious Diseases, this application proposes to develop the Pacific Center for Emerging Infectious Diseases Research at the University of Hawai'i at Manoa. By drawing on the complementary strengths and expertise within the John A. Burns School of Medicine, the Pacific Biomedical Research Center, and the Cancer Research Center of Hawai'i, as well as the State of Hawai'i Department of Health, the new Center will be anchored by the tenets of trans-disciplinary research. Projects will be linked by a unifying research focus on the molecular epidemiology and pathogenesis of infectious diseases, which are of local and regional relevance and which disproportionately affect under-served ethnic minority communities in Hawai'i and the Asia-Pacific region. Specifically, studies will be conducted on the natural history of human papillomavirus infection in heterosexual men, the immunopathogenesis of dengue fever, and the molecular epidemiology and adhesion properties on group A streptococci in relation to high-incidence acute rheumatic fever in Hawai'i. Newfound knowledge from these research projects will provide improved strategies for prevention and control of these regionally important infectious diseases. The overall objectives of the proposed Center will be achieved by the following specific aims: 1. Build institutional capacity by mentoring a cadre of promising young faculty to conduct research on infectious diseases of medical importance to the Asia-Pacific region. 2. Improve research competitiveness by enhancing the capacity for mentoring and expanding the capability of the technical support infrastructure. 3. Diversify the research breadth and trans-disciplinary scope of the Center through targeted recruitment and retention of funded faculty with complementary expertise and through centralization of laboratory space and research-support operations.