EFFECTS OF SELENIUM DEFICIENCY ON GENOMIC MUTATION OF RNA VIRUSES

缺硒对 RNA 病毒基因突变的影响

• 批准号: 7171208
• 负责人: SAGUNA VERMA
• 金额: $ 6.8万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171208
• 关键词: Hawaii; Pacific Islands; clinical research; communicable disease transmission; emerging infectious disease; human papillomavirus; human subject; molecular pathology

DESCRIPTION (provided by applicant): In response to a regional resurgence of infectious diseases and consistent with a high-priority institutional initiative to establish the Asia-Pacific Institute for Tropical Medicine and Infectious Diseases, this application proposes to develop the Pacific Center for Emerging Infectious Diseases Research at the University of Hawai'i at Manoa. By drawing on the complementary strengths and expertise within the John A. Burns School of Medicine, the Pacific Biomedical Research Center, and the Cancer Research Center of Hawai'i, as well as the State of Hawai'i Department of Health, the new Center will be anchored by the tenets of trans-disciplinary research. Projects will be linked by a unifying research focus on the molecular epidemiology and pathogenesis of infectious diseases, which are of local and regional relevance and which disproportionately affect under-served ethnic minority communities in Hawai'i and the Asia-Pacific region. Specifically, studies will be conducted on the natural history of human papillomavirus infection in heterosexual men, the immunopathogenesis of dengue fever, and the molecular epidemiology and adhesion properties on group A streptococci in relation to high-incidence acute rheumatic fever in Hawai'i. Newfound knowledge from these research projects will provide improved strategies for prevention and control of these regionally important infectious diseases. The overall objectives of the proposed Center will be achieved by the following specific aims: 1. Build institutional capacity by mentoring a cadre of promising young faculty to conduct research on infectious diseases of medical importance to the Asia-Pacific region. 2. Improve research competitiveness by enhancing the capacity for mentoring and expanding the capability of the technical support infrastructure. 3. Diversify the research breadth and trans-disciplinary scope of the Center through targeted recruitment and retention of funded faculty with complementary expertise and through centralization of laboratory space and research-support operations.

描述（由申请人提供）： 为了应对区域性传染病的死灰复燃，并与建立亚太热带医学和传染病研究所的高度优先机构倡议相一致，本申请提议在夏威夷大学马诺阿分校建立太平洋新发传染病研究中心。通过利用约翰·A·伯恩斯医学院、太平洋生物医学研究中心、夏威夷癌症研究中心以及夏威夷州卫生部的互补优势和专业知识，新中心将以跨学科研究的原则为基础。这些项目将通过对传染病的分子流行病学和发病机制的统一研究重点联系起来，这些研究具有地方和区域相关性，并且对夏威夷和亚太地区服务不足的少数民族社区造成不成比例的影响。具体而言，将针对异性恋男性中人乳头瘤病毒感染的自然史、登革热的免疫发病机制以及与夏威夷高发急性风湿热相关的 A 族链球菌的分子流行病学和粘附特性进行研究。这些研究项目中新发现的知识将为预防和控制这些区域性重要传染病提供改进的策略。拟议中心的总体目标将通过以下具体目标来实现： 1. 通过指导一批有前途的年轻教师开展对亚太地区具有医学重要性的传染病研究来建设机构能力。 2. 通过增强指导能力和扩大技术支持基础设施的能力来提高研究竞争力。 3. 通过有针对性地招募和保留具有互补专业知识的受资助教师以及通过集中实验室空间和研究支持业务，使中心的研究广度和跨学科范围多样化。