COBRE: OK MED RES FOUND: P3: GPI ANCHORING & TISSUE FACTOR PATHWAY INHIBITOR

COBRE：确定医学研究结果：P3：GPI 锚定

• 批准号: 7171275
• 负责人: Cristina Lupu
• 金额: $ 27.83万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171275
• 关键词: clinical research; host organism interaction; immune response; posttranslational modifications

DESCRIPTION (provided by applicant): This proposal for a Center for Biomedical Research Excellence (COBRE) originates from the Oklahoma Medical Research Foundation (OMRF). It includes key collaborations with the adjacent University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City and with the main campus of the University of Oklahoma (UO), located 20 miles south of Oklahoma City in Norman. The scientific theme is the role of glycosylation in host defense. Virtually all membrane and secreted proteins undergo post-translational modifications, particularly glycosylation. Yet the functions of these extremely diverse modifications remain poorly understood. Oklahoma has developed major strengths in this area. The proposal aims to build on these strengths by interfacing glycobiology with existing and emerging expertise in cardiovascular biology, bioengineering, and immunology. This interdisciplinary approach centers on active participation of productive, senior investigators in mentoring a group of promising junior investigators. New Core facilities will further enhance their research. The success of these junior investigators will enlarge the critical mass of talent in overlapping scientific areas, a synergistic method to expand the biomedical research infrastructure in Oklahoma.

描述（由申请人提供）： 这个生物医学研究卓越中心（COBRE）的提案来自俄克拉荷马州医学研究基金会（OMRF）。它包括与邻近的俄克拉荷马州市的俄克拉荷马州大学健康科学中心（OUHSC）以及位于诺曼市俄克拉荷马州以南20英里的俄克拉荷马州大学（UO）主校区的重要合作。科学主题是糖基化在宿主防御中的作用。几乎所有的膜蛋白和分泌蛋白都经历翻译后修饰，特别是糖基化。然而，这些极其不同的修饰的功能仍然知之甚少。俄克拉荷马州在这一领域发展了主要优势。该提案旨在通过将糖生物学与心血管生物学，生物工程和免疫学方面现有和新兴的专业知识相结合来建立这些优势。这种跨学科的方法集中在积极参与生产，资深研究人员在指导一组有前途的初级研究人员。新的核心设施将进一步加强他们的研究。这些初级研究人员的成功将扩大重叠科学领域的人才临界质量，这是一种扩大俄克拉荷马州生物医学研究基础设施的协同方法。