Development of a new approach to targeted chelation therapies

过渡金属离子的螯合已被证明在治疗许多疾病中是有益的。通过螯合金属离子，可以抑制生物途径，改变蛋白质折叠状态。然而，金属离子是无数生物过程所必需的，因此传统的螯合疗法可能具有不必要的副作用。通过将螯合剂连接到能够靶向特定生物靶点的东西上，这将有助于防止这些副作用。该项目将开发一种新的方法，通过将小分子金属螯合剂连接到靶向肽，以最大限度地减少脱靶效应。

Chelation of transition metal ions has been shown to be of benefit in treating many diseases. Through the sequestering of metal ions biological pathways can be inhibited and protein folding states altered. Metal ions however are required for myriad biological processes and thus traditional chelation therapies can have unwanted side effects. By attaching a chelator to something able to target a specific biological target this would help prevent these side effects. This project will develop a new approach by attaching small molecule metal chelators to targeting peptides to minimise off target effects.