Development of a new approach to targeted chelation therapies

过渡金属离子的螯合已被证明有益于治疗许多疾病。通过隔离金属离子，可以抑制生物途径并改变蛋白质折叠状态。然而，多种生物过程都需要金属离子，因此传统的螯合疗法可能会产生不良副作用。通过将螯合剂附加到能够针对特定生物靶标的物质上，这将有助于防止这些副作用。该项目将开发一种新方法，将小分子金属螯合剂附着到靶向肽上，以尽量减少脱靶效应。

Chelation of transition metal ions has been shown to be of benefit in treating many diseases. Through the sequestering of metal ions biological pathways can be inhibited and protein folding states altered. Metal ions however are required for myriad biological processes and thus traditional chelation therapies can have unwanted side effects. By attaching a chelator to something able to target a specific biological target this would help prevent these side effects. This project will develop a new approach by attaching small molecule metal chelators to targeting peptides to minimise off target effects.