3D bioprinted hydrogel models for the study and treatment of human liver disease

用于研究和治疗人类肝脏疾病的 3D 生物打印水凝胶模型

• 批准号: 2879464
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2879464
• 关键词: 3D; bioprinted; hydrogel; models; study

Fully-funded PhD studentship on 3D bioprinted vascular branches reinforced with nanofibre mesh. This is a standard 3.5-year UK PhD. The lack of vascularization is the main bottleneck of bioprinting functional organs. This project aims at developing a vascular tree consisting of arteries, veins, and ureter, for artificial kidney development. The student will learn how to operate our novel home-built hybrid 3D bioprinter, which combines hydrogel printing with electrospinning. The student will make polymeric solutions for electrospinning and for bioprinting hydrogels, and work with cell cultures. The generated hybrid structures will be characterized by microscopy techniques (SEM, confocal laser scanning microscopy, fluorescence microscopy, etc.) and by assessing the mechanical performance. Within the project the student will use state-of-the-art characterization techniques. Half of the work will be carried out at the Swiss Federal Laboratories for Materials Science and Technology (Empa) in St. Gallen, Switzerland, a material research institute belonging to the ETH domain (Swiss Federal Institute of Technology).

全额资助的3D生物打印血管分支用纳米纤维网加固的博士研究生。这是一个标准的3.5年制英国博士学位。血管生成不足是生物打印功能器官的主要瓶颈。该项目旨在开发一种由动脉、静脉和输尿管组成的血管树，用于人工肾的开发。学生将学习如何操作我们新型的自制混合3D生物打印机，它结合了水凝胶打印和静电纺丝。学生将制作用于静电纺丝和生物打印水凝胶的聚合物解决方案，并与细胞培养一起工作。生成的混合结构将通过显微镜技术(扫描电子显微镜、激光共聚焦扫描显微镜、荧光显微镜等)进行表征。并对其机械性能进行了评估。在这个项目中，学生将使用最先进的人物刻画技术。一半的工作将在瑞士圣加伦的瑞士联邦材料科学与技术实验室(EMPA)进行，这是一家属于ETH领域(瑞士联邦理工学院)的材料研究所。