UNIVERSITY OF HAWAII SNRP

本提案是根据RFA NS-99-001编写的，描述了该少数族裔机构的专门神经科学研究计划。Bekesy神经生物学实验室为SNRP提供了一个合适的地点，并将通过请求的奖励得到极大的加强。三名青年教师已被选中，他们已经制定了合作建议，涉及一名研究密集型机构的调查员。项目1-涉及刺胞菌毒液中新型神经活性化合物的表征。这项工作将与约翰霍普金斯大学的研究人员合作进行，他们在这一领域的工作很有名。项目2-询问位于中枢神经系统内的细胞毒性T淋巴细胞是否导致对HIV-1的神经毒性毒株的选择，从而启动艾滋病痴呆复合体，作为这一选择过程的延迟结果。这项工作将与西雅图华盛顿大学的一位经验丰富的研究者合作进行。项目3-寻求表征微生物剂负责一种形式的脑脊髓炎发现在一个特定的西伯利亚人口。然而，外来移民的患病率与本地人口的患病率相同。这项工作将与一名在传染病研究方面有经验的研究所校内调查员合作进行。已经建立了内部和外部咨询委员会，以进一步协助选定的教师发展他们独立的神经科学研究事业。该奖项将大大改善服务不足的少数民族在该机构获得高质量神经科学研究培训的机会。

This proposal has been prepared in response to RFA NS-99-001, and describes a Specialized Neuroscience Research Program for this Minority Institution. The Bekesy Laboratory of Neurobiology provides an appropriate site for this SNRP and would be greatly strengthened by the requested award. Three junior faculty have been selected, who have developed collaborative proposals involving an investigator at a research- intensive institution. Project 1- involves characterization of novel neuroactive compounds from Cnidaria venoms. This work will be carried out in collaboration with investigators from Johns Hopkins University who are well-known for their work in this area. Project 2- asks whether cytotoxic T lymphocytes located within the central nervous system lead to selection on neurovirulent strains of HIV-1 thus initiating AIDS dementia complex as a delayed result of this selection process. This work will be carried out in collaboration with an experienced investigator at the University of Washington, Seattle. Project 3- seeks to characterize the microbial agent responsible for a form of encephalomyelitis found in a specific Siberian population. However, prevalence is the same in-migrants as in the native population. This work will be carried out in collaboration with an NINDS Intramural investigator experienced in study of infectious diseases. Internal and External Advisory committees have been established to further assist the selected faculty in developing their independent neuroscience research careers. This award will substantially improve opportunities for underserved minorities to obtain high-quality research training in neurosciences at this institution.