CORE SUPPORT AS AN NGVL TOXICOLOGY CENTER

作为 NGVL 毒理学中心的核心支持

• 批准号: 7360456
• 负责人: JOHN G PAGE
• 金额: $ 19.21万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7360456
• 关键词: CORE; SUPPORT; NGVL; TOXICOLOGY; CENTER

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Deletion or mutation of a single gene may result in a specific disease. Sequencing of the human genome has led to huge efforts to identify and isolate specific genes involved in the etiology of various diseases, including cancer, AIDS, diabetes, and cystic fibrosis. During the past decade, a number of gene therapies have been developed to replace defective or deleted genes with normal, functional genes. While gene therapy holds great potential for the treatment and/or cure of various diseases, it is not without risk, as demonstrated in 1999 when a teenager became the first known person in the country to die as a direct result of gene therapy.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。描述（由申请人提供）：单个基因的缺失或突变可能导致特定疾病。人类基因组测序已经导致了巨大的努力，以确定和分离涉及各种疾病的病因学的特定基因，包括癌症，艾滋病，糖尿病和囊性纤维化。在过去的十年中，已经开发了许多基因疗法，以用正常的功能基因取代有缺陷或缺失的基因。虽然基因疗法在治疗和/或治愈各种疾病方面具有巨大潜力，但它并非没有风险，1999年一名青少年成为该国已知的第一个直接因基因疗法而死亡的人。