Generating endogenous antigen specific T regulatory cells to treat autoimmune MPO-ANCA GN

生成内源性抗原特异性 T 调节细胞来治疗自身免疫性 MPO-ANCA GN

• 批准号: nhmrc : GNT1147388
• 负责人: Dr Joshua Ooi
• 金额: $ 87.33万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generating-endogenous-antigen-anca-gn/1348819
• 关键词: Generating; endogenous; antigen; specific; regulatory

Glomerulonephritis (GN) is an inflammatory disease that affects the filtering organs (glomeruli) of the kidney. The most severe and aggressive form is ANCA-associated GN resulting from loss of tolerance to myeloperoxidase (MPO). Current therapies are toxic. This study will develop new strategies to restore immune tolerance to MPO thus treating patients with this disease. We will use an animal model to provide proof-of-concept that these novel therapies can treat MPO-ANCA associated GN.

肾小球肾炎（GN）是一种影响肾脏滤过器官（肾小球）的炎症性疾病。最严重和侵袭性的形式是ANCA相关的GN，其由对髓过氧化物酶（MPO）的耐受性丧失引起。目前的治疗是有毒的。这项研究将开发新的策略来恢复对MPO的免疫耐受，从而治疗这种疾病的患者。我们将使用动物模型来提供这些新疗法可以治疗MPO-ANCA相关GN的概念验证。