Novel immunomodulatory therapeutic strategies to target intracellular pathogens

针对细胞内病原体的新型免疫调节治疗策略

• 批准号: 2881974
• 金额: --
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2881974
• 关键词: Novel; immunomodulatory; therapeutic; strategies; target

This is an exciting opportunity to work in the area of therapeutics and drug discovery at LSTM. You will be integrated into an extremely active research group with a diverse research portfolio. Projects will work towards the identification of novel therapeutic strategies targeting key intracellular pathogens (Mycobacterium tuberculosis, Nisseria gonorrhoeae, Salmonella enterica). Projects will utilise ex vivo human models of infection, advanced analytical techniques (confocal microscopy and flow cytometry), and pharmacodynamic-pharmacokinetic (PK-PD) modelling to study pathogenesis, resistance emergence, and to assess the clinical tractability of novel therapeutics. Projects will be tailored to the candidate and provide opportunity for industry training and overseas placement.

这是一个令人兴奋的机会，可以在LSTM的治疗和药物发现领域工作。您将被整合到一个非常活跃的研究小组，拥有多样化的研究组合。项目将致力于确定针对关键细胞内病原体（结核分枝杆菌、淋病奈瑟菌、肠道沙门氏菌）的新治疗策略。项目将利用离体人类感染模型、先进的分析技术（共聚焦显微镜和流式细胞术）和药效学-药代动力学（PK-PD）建模来研究发病机制、耐药性出现，并评估新型疗法的临床可操作性。项目将为候选人量身定制，并提供行业培训和海外就业的机会。