Experimental Analysis of Advanced Radiotherapy Dosimetry
先进放射治疗剂量测定的实验分析
基本信息
- 批准号:7221161
- 负责人:
- 金额:$ 18.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-03-18 至 2008-02-29
- 项目状态:已结题
- 来源:
- 关键词:AccountingAlgorithmsArtsBenchmarkingCase StudyClassificationClinicalClinical TreatmentCodeCollimatorConformal RadiotherapyCorvusDataDevelopmentDoseEatingEnsureError SourcesExcisionFailureFeedbackFilmFilm DosimetryFrequenciesGamma CamerasHeadHead and neck structureImageIndividualInstructionIntensity-Modulated RadiotherapyIonizing radiationLaboratoriesLeadLinear Accelerator Radiotherapy SystemsLocationMeasurementMeasuresMechanicsModalityModelingMotionNormal tissue morphologyOrganOutcomePatientsPersonal SatisfactionPhasePhotonsPlant LeavesRadiationRadiation therapyRelative (related person)ResolutionRoleShapesSourceSpeedStandards of Weights and MeasuresSystemTechniquesTestingUncertaintyWorkX-Ray Filmbaseclinically significantdesigndesiredosimetryexperimental analysisimprovednovelresearch studysimulationtransmission processtreatment planning
项目摘要
DESCRIPTION (provided by applicant): The overall aim of this project is to understand the role of nontrivial systematic errors in the overall accuracy of multileaf collimator (MLC) -based megavoltage (MV) photon-beam intensity modulated radiation therapy (IMRI-) delivery and dose calculation. According to our preliminary data, nontrivial systematic errors in IMRT delivery and plan calculation exist with significant frequency and have the potential to conspire to be clinically significant. A complete experimental characterization of static and dynamic MLC-based IMRT delivery is proposed. This experimental characterization includes the accurate simultaneous measurement of the dose distributions produced by IMRT using a novel radiochromic film dose-imaging system, and the delivered field shapes and fluences using a high-speed scintillation camera system. Results from this work will provide a ranking of the importance of the different sources of error for the development of strategies to minimize IMRT delivery errors. The data from this characterization will allow mechanical misalignment and dose delivery errors to be compensated for by incorporating the feedback of these measured parameters into a treatment-planning algorithm. From this vantage, the accuracy of the IMRT dose calculational algorithms will be assessed. Results from this work will provide a paradigm for closing the loop between the clinical treatment planning system and the MLC IMRT delivery system.
描述(由申请人提供):本项目的总体目标是了解非平凡系统误差在基于多叶准直器(MLC)的兆伏(MV)光子束调强放射治疗(IMRI-)输送和剂量计算的总体准确性中的作用。根据我们的初步数据,在调强放射治疗的交付和计划计算的非平凡的系统误差存在显着的频率,并有可能阴谋是临床意义。提出了一个完整的静态和动态MLC的调强放射治疗交付的实验表征。该实验表征包括使用新型辐射变色膜剂量成像系统对IMRT产生的剂量分布进行精确的同时测量,以及使用高速闪烁相机系统对所提供的场形状和注量进行精确的同时测量。从这项工作的结果将提供一个排名的重要性,不同来源的错误的发展战略,以尽量减少调强放射治疗的交付错误。来自该表征的数据将允许通过将这些测量参数的反馈结合到治疗计划算法中来补偿机械未对准和剂量输送误差。从这个Vantage出发,将评估IMRT剂量计算算法的准确性。这项工作的结果将提供一个范例,关闭临床治疗计划系统和MLC调强放射治疗输送系统之间的循环。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Comparison of two commercial detector arrays for IMRT quality assurance.
- DOI:10.1120/jacmp.v10i2.2942
- 发表时间:2009-04-29
- 期刊:
- 影响因子:2.1
- 作者:Li JG;Yan G;Liu C
- 通讯作者:Liu C
Comparison of small photon beams measured using radiochromic and silver-halide films in solid water phantoms.
在固体水体模中使用放射变色膜和卤化银膜测量的小光子束的比较。
- DOI:10.1118/1.1788931
- 发表时间:2004
- 期刊:
- 影响因子:3.8
- 作者:Zeidan,OmarA;Li,JonathanG;Low,DanielA;Dempsey,JamesF
- 通讯作者:Dempsey,JamesF
A high-speed scintillation-based electronic portal imaging device to quantitatively characterize IMRT delivery.
一种基于高速闪烁的电子射野成像设备,用于定量表征 IMRT 传输。
- DOI:10.1118/1.2143142
- 发表时间:2006
- 期刊:
- 影响因子:3.8
- 作者:Ranade,ManishaK;Lynch,BartD;Li,JonathanG;Dempsey,JamesF
- 通讯作者:Dempsey,JamesF
Comparative analysis of 60Co intensity-modulated radiation therapy.
60Co调强放射治疗的对比分析。
- DOI:10.1088/0031-9155/53/12/007
- 发表时间:2008
- 期刊:
- 影响因子:3.5
- 作者:Fox,Christopher;Romeijn,HEdwin;Lynch,Bart;Men,Chunhua;Aleman,DionneM;Dempsey,JamesF
- 通讯作者:Dempsey,JamesF
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JAMES F DEMPSEY其他文献
JAMES F DEMPSEY的其他文献
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{{ truncateString('JAMES F DEMPSEY', 18)}}的其他基金
Experimental Analysis of Advanced Radiotherapy Dosimetry
先进放射治疗剂量测定的实验分析
- 批准号:
7025062 - 财政年份:2004
- 资助金额:
$ 18.62万 - 项目类别:
Experimental Analysis of Advanced Radiotherapy Dosimetry
先进放射治疗剂量测定的实验分析
- 批准号:
6725890 - 财政年份:2004
- 资助金额:
$ 18.62万 - 项目类别:
Experimental Analysis of Advanced Radiotherapy Dosimetry
先进放射治疗剂量测定的实验分析
- 批准号:
6868833 - 财政年份:2004
- 资助金额:
$ 18.62万 - 项目类别:
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