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New Opportunities in Enantioselective Catalysis Using Lewis Acidic Boranes

使用路易斯酸性硼烷进行对映选择性催化的新机遇

基本信息

批准号：
2882637
负责人：
金额：
--
依托单位：
CARDIFF UNIVERSITY
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2882637
关键词：
New Opportunities Enantioselective Catalysis Using

项目摘要

Main group chemistry is a topical area of research that has undergone a renaissance in the past 20 years. This can partly be attributed to the unique chemistry and reactivity exhibited by main group compounds, which can offer complementarity to transition metal catalysis. Furthermore, there is an increasing global challenge to develop catalytic methods to produce chemicals for society that provide alternatives to catalysts based on precious metals. As such, the central goal of this PhD studentship is the development of novel methodologies that employ main group catalysts, diversifying their reactivity profile, which is an important and timely pursuit. To this end, a collection of challenging enantioselective transformations employing Lewis acidic boranes will been developed. This program will significantly advance main group catalysis through the development of stereoselective synthetic methods. A highly motivated and dedicated student will gain a thorough training in synthetic organic chemistry / main group catalysis, and be rewarded with a highly stimulating project that will shape the future of this exciting new research program. Recent publications from the supervisors in this area include Org. Lett. 2022, 24, 8694, Chem. Eur. J., 2022, 28, e202202454, Chem. Soc. Rev., 2021, 50, 3720, ACS Catal., 2020, 10, 4835, Angew. Chem. Int. Ed., 2018, 57, 12356, ACS Catal., 2017, 7, 7748.The student will be co-supervised by a member of the Chemical Development team at AstraZeneca, and will spend 3-months on site at AstraZeneca during the course of the PhD.

主族化学是一个热门的研究领域，在过去的20年里经历了复兴。这可以部分归因于主族化合物所表现出的独特化学和反应性，其可以为过渡金属催化提供补充。此外，开发催化方法为社会生产化学品，为基于贵金属的催化剂提供替代品，这是一项日益严峻的全球挑战。因此，这个博士研究生的中心目标是开发采用主族催化剂的新方法，使其反应性特征多样化，这是一个重要而及时的追求。为此，将开发一系列采用刘易斯酸性硼烷的具有挑战性的对映选择性转化。该计划将通过立体选择性合成方法的发展显着推进主基催化。一个高度积极和敬业的学生将获得合成有机化学/主基催化的全面培训，并获得一个高度刺激的项目，将塑造这个令人兴奋的新研究计划的未来。主管人员最近在这一领域的出版物包括《组织通讯》。2022，24，8694，Chem. Eur. J.，2022，28，e202202454，Chem. Soc. Rev.，2021，50，3720，ACS Catal.，2020年10月4835日，Angew.化学国际版，2018，57，12356，ACS Catal.，2017年，7，7748.学生将由阿斯利康化学开发团队的一名成员共同监督，并将在博士课程期间在阿斯利康现场度过3个月。