Genes and Environment in the Risk of Early Age-Related Macular Degeneration: A Population-based Case-Control Study

早期年龄相关性黄斑变性风险中的基因和环境：基于人群的病例对照研究

• 批准号: nhmrc : 512423
• 负责人: Prof Jie Jin Wang
• 金额: $ 63.32万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genes-environment-risk-control-study/82582
• 关键词: Genes; Environment; Risk; Early; Age

This study will pool data from three well-conducted population-based cohorts of older persons to gain a large sample size in order to investigate the interplay of genes and environmental factors on the risk of age-related macular degeneration (AMD). The study will give insights into AMD pathogenesis, and enable potential targeting of people with AMD susceptibility genes for preventive approaches. These could ultimately reduce the burden of this blinding condition.

这项研究将汇集来自三个进行良好的基于人群的老年人队列的数据，以获得大样本量，以调查基因和环境因素对年龄相关性黄斑变性（AMD）风险的相互作用。这项研究将深入了解AMD的发病机制，并使潜在的目标人群与AMD易感基因的预防方法。这些最终可以减轻这种设盲状况的负担。