Base Metal Catalysis for the Mild Production of Carbocation-like Intermediates

贱金属催化温和生产类碳阳离子中间体

• 批准号: 2883980
• 金额: --
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2883980
• 关键词: Base; Metal; Catalysis; Mild; Production

The role of organic synthesis in modern society is undeniable, with various industries relying on synthetic pathways to create natural and designed molecules, improving our everyday lives. In the realm of drug discovery, the development of new and efficient reaction methods is essential for producing therapeutics with high efficacy and minimal side effects. Overcoming challenges related to selectivity, efficiency, and sustainability is critical for these new synthetic techniques to have a significant impact.One promising avenue of research involves the mild generation of reactive intermediates, such as radicals and carbocations, to facilitate the construction of new molecular structures. These intermediates have the unique ability to make compounds that are not easily accessible by other synthetic routes. However, their application in synthetic strategies has been limited by the lack of precise control over chemo- and stereoselectivity, as well as the harsh conditions often required for their generation.In this research project, we aim to address these limitations by developing a sustainable method for the controlled generation of carbocation-like intermediates under mild conditions. An integral part of this approach is the utilisation of cobalt catalysis, which is not only effective but also more sustainable than using precious metal catalysts. Through these innovative reactions, our project seeks to expand the repertoire of accessible molecules, enabling the creation of diverse compounds with applications across various industries.

有机合成在现代社会中的作用是不可否认的，各种行业依靠合成途径来创造自然和设计的分子，改善我们的日常生活。在药物发现领域，开发新的、高效的反应方法对于生产高效、副作用最小的治疗药物至关重要。克服与选择性、效率和可持续性相关的挑战是这些新的合成技术产生重大影响的关键。一个有前途的研究途径包括温和生成活性中间体，如自由基和碳正离子，以促进新分子结构的构建。这些中间体具有独特的能力，可以生产其他合成路线不易获得的化合物。然而，由于缺乏对化学和立体选择性的精确控制以及合成条件的苛刻，它们在合成策略中的应用一直受到限制。在本研究项目中，我们旨在通过开发一种可持续的方法在温和的条件下控制类碳阳离子中间体的生成来解决这些限制。这一方法的一个组成部分是利用钴催化，这不仅有效，而且比使用贵金属催化剂更可持续。通过这些创新的反应，我们的项目寻求扩大可访问分子的谱系，使各种化合物的创建能够在不同的行业中应用。