Exploring the role of vitamin transport in insect models of disease vector biology

探索维生素运输在病媒生物学昆虫模型中的作用

• 批准号: 2884651
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2884651
• 关键词: Exploring; role; vitamin; transport; insect

Vector-borne diseases of plants, livestock and humans are infections transmitted by arthropods feeding on host plants or animals. These diseases have huge worldwide economic, social and health costs.Micronutrients such as vitamins are essential for all forms of animal life. However, many invertebrates thrive despite feeding exclusively on diets deficient in vitamins. Adequate nutrition is achieved via mutualistic relationships with heritable microbes which provide the micronutrients lacking in diet. This obligate nutritional symbiosis is most striking in insects feeding exclusively on vitamin deficient vertebrate blood or plant sap, insects that often act as vectors of human/livestock/plant diseases and have huge global economic impacts on crop production, food biosecurity, animal and human health.Hypothesis: Molecular mechanisms of vitamin transport are fundamental for the persistence of endosymbiosis in obligate blood- and sap- feeding insects and, thus, the success of many invertebrate disease vectors.Vitamin provision is central to endosymbiotic relationships and host insect success, but little is known about the molecular mechanisms involved in vitamin transport in insects. How are microbe-derived vitamins delivered to the bacteriocyte cytosol across the symbiosomal membrane, or to insect haemolymph across the bacteriocyte plasma membrane? By analysing recent genomic/transcriptomic information from blood- and sap-feeding insects, candidate vitamin transporters will be identified and characterised functionally. Understanding the molecular basis of endosymbiotic relationships will shed light on a fundamental aspect of arthropod biology and underpin the development of novel disease vector control strategies centred on transporter biology.Molecules, Cells and Industrial Biotechnology

植物、牲畜和人类的病媒传染病是由以宿主植物或动物为食的节肢动物传播的感染。这些疾病在世界范围内造成巨大的经济、社会和健康成本。然而，许多无脊椎动物尽管只以缺乏维生素的饮食为食，但仍能茁壮成长。充足的营养是通过与遗传微生物的互利关系实现的，这些微生物提供饮食中缺乏的微量营养素。这种专性营养共生在专门以缺乏维生素的脊椎动物血液或植物汁液为食的昆虫中最为显著，这些昆虫经常充当人类/牲畜/植物疾病的载体，并对作物生产、食品生物安全、动物和人类健康产生巨大的全球经济影响。维生素转运的分子机制是专性吸血和树液取食昆虫内共生持续存在的基础，因此，维生素供应是内共生关系和宿主昆虫成功的核心，但对昆虫中维生素运输所涉及的分子机制知之甚少。微生物来源的维生素是如何穿过共生体膜进入细菌细胞胞质溶胶或穿过细菌细胞质膜进入昆虫血淋巴的？通过分析最近的基因组/转录信息的血液和树液喂养昆虫，候选维生素转运蛋白将被确定和功能特点。了解内共生关系的分子基础将有助于阐明节肢动物生物学的一个基本方面，并支持以转运蛋白生物学为中心的新型病媒控制策略的发展。