Investigating the role of senescence in musculoskeletal ageing

随着年龄的增长，包括骨骼在内的许多组织都会积累衰老的“僵尸”细胞，造成损伤和功能障碍。该博士项目将使用体外细胞培养模型、生物化学和细胞生物学，以及活体斑马鱼模型来研究健康细胞和衰老细胞的生长、代谢和生存途径的不同。此外，我们将研究衰老如何促进与年龄相关的骨骼修复和再生能力的变化，以应对攻击。我们将利用这些知识来开发新的干预措施来“杀死”衰老细胞，并测试这是否能改善或恢复老化的骨骼。总的来说，我们正在努力理解和改善健康老龄化。

The accumulation of senescent, 'zombie' cells occurs in many tissues with age, including bone, causing damage anddysfunction. This PhD project will use in vitro cell culture models, biochemistry and cell biology, as well as in vivozebrafish models to investigate how growth, metabolism and survival pathways are different in healthy andsenescent cells. Alongside, we will investigate how senescence contributes to age-related changes in the ability of boneto properly repair and regenerate in response to assaults. We will use this knowledge to develop novel interventions to'kill' senescent cells and test whether this improves or rejuvenates ageing bones. Overall we are working to understandand improve healthy ageing.