Investigating the role of senescence in musculoskeletal ageing

研究衰老在肌肉骨骼衰老中的作用

• 批准号: 2884952
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2884952
• 关键词: Investigating; role; senescence; musculoskeletal; ageing

The accumulation of senescent, 'zombie' cells occurs in many tissues with age, including bone, causing damage anddysfunction. This PhD project will use in vitro cell culture models, biochemistry and cell biology, as well as in vivozebrafish models to investigate how growth, metabolism and survival pathways are different in healthy andsenescent cells. Alongside, we will investigate how senescence contributes to age-related changes in the ability of boneto properly repair and regenerate in response to assaults. We will use this knowledge to develop novel interventions to'kill' senescent cells and test whether this improves or rejuvenates ageing bones. Overall we are working to understandand improve healthy ageing.

随着年龄的增长，衰老的“僵尸”细胞在包括骨骼在内的许多组织中积累，导致损伤和功能障碍。这个博士项目将使用体外细胞培养模型，生物化学和细胞生物学，以及体内斑马鱼模型来研究健康和衰老细胞的生长，代谢和生存途径是如何不同的。同时，我们将研究衰老如何有助于骨骼在应对攻击时正确修复和再生能力的年龄相关变化。我们将利用这些知识开发新的干预措施来“杀死”衰老细胞，并测试这是否会改善或恢复衰老的骨骼。总的来说，我们正在努力理解和改善健康的老龄化。