GENERAL CLINICAL RESEARCH CENTER

德克萨斯大学加尔维斯顿综合临床研究中心医学分部（UTMB GCRC）自1963年以来一直在美国国立卫生研究院（NIH）的持续资助下运作。该中心的长期目标是提供设施和资源，以协助UTMB研究人员进行高质量的以患者为导向的研究。我们的首要任务是帮助那些从NIH获得同行评议资助的科学家，但我们的任务包括研究人员与其他形式的资助。UTMB GCRC还为精心设计的试点研究提供资源，以帮助个人寻求新的校外资金。为了满足临床研究人员不断变化的需求，该中心具有适应性。这一继续申请包括建议提供gcrc提供的新服务，以集中目前无法获得或由几个调查人员重复的程序。这些新服务包括一个生理核心实验室、卫星门诊支持以及对GCRC睡眠实验室和GCRC身体成分实验室的额外支持。目前提供的设施和资源包括住院室；三个独立的门诊设施，经验丰富的研究护士和饮食人员；代谢厨房：一个先进的手术室；一个40K的身体成分计数器；以及先进的计算机网络。扩大的教育活动包括每周为研究员和教员开设的GCRC课程课程，为医科学生开设的选修课程，为研究生提供研究机会，以及一年一度的临床研究研讨会。UTMB GCRC是一个机构资源，为95名研究人员提供服务，其中33名是65项GCRC研究方案的主要研究人员。在GCRC方案的主要研究人员中，94%有其他校外资金来支持他们面向患者的研究。这些调查人员中有64%是由NIH或其他联邦机构资助的主要调查人员。UTMB GCRC的用户来自12个系，来自30多个已确定的跨学科研究项目，以及医学院、护理学院、生物医学科学研究生院和联合健康学院。在GCRC的支持下开展的研究通过在理解正常人体生理学、疾病发病机制和评估创新新疗法方面的重要进展，直接或间接地影响医疗保健。在烧伤患者和糖尿病性溃疡患者中研究伤口愈合的代谢和内分泌方面，目的是改变伤口环境以促进愈合。其他研究增加了对罕见遗传疾病和具有明显种族决定因素的疾病的代谢、营养和环境方面的认识。UTMB艾滋病临床试验单位的科学家利用GCRC研究艾滋病毒新疗法的基本方面。环境科学和癌症是UTMB的主要研究主题。GCRC关于子宫内膜癌发病机制以及饮食和环境中影响癌症风险的物质的研究与这些主题是一致的。神经科学是UTMB的优势，正如GCRC关于疼痛和胃肠运动的协议所反映的那样。GCRC未来的计划包括提供一个新的和扩大的地点，更多地参与临床试验，增强计算机图像分析能力，扩大远程医疗活动，并增加对该大学所服务的大量监狱人口相关研究的关注。UTMB打算GCRC仍然是该校园以患者为导向的研究和新研究者教育的中心资源。

The University of Texas Medical Branch at Galveston General Clinical Research Center (UTMB GCRC) has been in operation with continuous funding from the National Institutes of Health (NIH) since 1963. The long-term of this center is to provide facilities and resources to assist UTMB investigators in performing high quality patient-oriented research. Our first priority is to help support those scientists who have peer- reviewed funding from the NIH, but our mission includes of investigators with other forms of funding. The UTMB GCRC also provides resources for well designed pilot studies to assist individuals in pursuing new extramural funding. In order to meet the changing needs of clinical researchers, this center is adaptable. This continuation application includes proposals for new GCRC-provided services to centralize procedures that are currently unavailable or are duplicated by several investigators. These new services include a Physiologic Core Laboratory, satellite outpatient support, and additional support for the GCRC Sleep Laboratory and the GCRC Body Composition Laboratory. The facilities and resources that are currently provided include inpatient rooms; three separate outpatient facilities, experienced research nurses and dietary staff; and metabolic kitchen: an advanced procedure room; a 40K counter for body composition; and an advanced computer network. Expanded educational activities include a GCRC Curriculum Course with weekly sessions for fellows and faculty, an elective course for medical students, research opportunities for graduate students, and an annual Clinical Research Colloquium. The UTMB GCRC is an institutional resource that serves 95 investigators, of whom 33 are principal investigators on 65 GCRC research protocols. Of the GCRC protocol principal investigators, 94% have other extramural funding to support their patient-oriented research. Sixty-four percent of these investigators are principle investigators on grants from NIH or other federal agencies. The UTMB GCRC has users from 12 departments, from ore than 30 identified interdisciplinary research programs, and from the School of Medicine, School of Nursing, Graduate School of Biomedical Sciences, and the School of Allied Health. The research conducted with the support the GCRC impacts health care directly and indirectly through important advances in understanding of normal human physiology, the pathogenesis of disease, and the evaluation of innovative new therapies. Metabolic and endocrine aspects of wound healing are studied in burn patients and patients with diabetic ulcers, with the aim of modifying the wound environment to promote healing. Other studies have increased knowledge about metabolic, nutritional and environmental aspects of rare genetic diseases and diseases with pronounced ethnic determinants. Scientists from the UTMB AIDS Clinical Trials Unit use the GCRC for studies of fundamental aspects of new therapies for HIV. Environmental science and cancer are major research themes at UTMB. GCRC studies on the pathogenesis of endometrial cancer and on substances in the diet and the environment that influence cancer risk are consistent with these themes. Neuroscience is a strength at UTMB, as reflected in GCRC protocols on pain and gastrointestinal motility. Future plans for the GCRC include providing a new and expanded location, greater involvement with clinical trials, enhanced capabilities for computer image analysis, expanded telemedicine activities, and increased attention to research relevant to the large prison population served by this university. UTMB intends that the GCRC remain the central resource on this campus for patient-oriented research and new investigator education.