Development of remote quantum sensing using photonic technologies

在利兹大学，我们正在研究基于光的非侵入性技术来测量身体的重要参数。该技术的核心依赖于本土开发的荧光材料平台，其通过使用短脉冲（飞秒，fs）和高功率激光产生的等离子体对玻璃材料进行表面工程。一般的想法是用玻璃上的这种薄功能表面产生的荧光照射皮肤，在低功率激光激发下，与血液和间质液中的生物分子相互作用，提供光学响应。信号的变化提供了所研究的生物标志物的分子特异性浓度信息。作为生物传感器开发的第一步，该技术已被研究用于糖尿病患者的非侵入性葡萄糖感测，以提供更快，更方便的替代方案，相对于当前的针和基于血液的测量，患者舒适度更高（无疼痛）。然而，该设备的性能可以进一步改进并应用于其他场景，需要优化传感器材料的设计和制造。光学传感的挑战需要从工程和量子光学两个方面进行评估。项目的具体目标：发展改进的量子理论以获得更好的传感设计一种新的实验装置来测试预测增强的灵敏度和选择性的量子光学模型优化改进的玻璃层以获得非侵入性传感器性能，特别是计划使用二阶光子相关函数的测量来获得更好的生物传感器性能。建立适用于临床前和临床研究的传感设备原型的质量标准

At the University of Leeds, we are investigating light based non-invasive techniques to measure the body vital parameters. The heart of this technique relies on an indigenously developed fluorescent material platform by the surface engineering of glass materials using a short pulse (femtosecond, fs) and high power laser produced plasma. The general idea is to shine the skin with fluorescence light produced by this thin functional surface on glass, under low power laser excitation, interacts with biomolecules in blood and interstitial fluid providing optical response. The variation in the signal provides molecule specific concentration information of the biomarker under investigation. As a first step in the development of the biosensor, the technology has been investigated for non-invasive glucose sensing for patients with diabetes to provide a faster, and convenient alternative at an increased patient comfort (no pain) relative to the current needle and blood-based measurements. However, the performance of the device can be further improved and applied to other scenarios and requires optimisation of the design and fabrication of sensor materials. The challenges in optical sensing need to be evaluated both from engineering and quantum optics aspects. Specific aims of the project: Develop modified quantum theories for better sensing Design a new experimental apparatus to test the quantum optical models which predict enhanced sensitivity and selectivity Optimise the modified glass layer for non-invasive sensor performances especially plan to use measurements of second-order photon correlation functions to obtain better biosensor performance. Establish specifications for the prototyping of sensing device suitable for preclinical and clinical investigations