Microbiological Characterisations of Dental Implants with Anti-infective and Photo-active Coating

具有抗感染和光敏涂层的牙种植体的微生物学特征

• 批准号: 2885459
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885459
• 关键词: Microbiological; Characterisations; Dental; Implants; Anti

The research will focus on engineering anti-infective and photoactive coating of standard dental implants, which are made from Ti-alloys. The anti-infective/photoactive coatings will be designed using fluorapatite minerals. Coating will be carried out using spin coating and laser sintering. The properties of implants will be characterised using hardness measurements, FTIR, Raman, UV-Visible, Photoluminescence, oximetric measurements using the characterisations of oxyhaemoglobin and deoxy-haemoglobin. The coated implants will be tested in osteoblast, endothelial cell cultures and also co-cultured with anaerobic/aerobic bacteria for the identification active proteins in situ. The materials characterisations will be carried out using X-ray diffraction, TEM/SEM, and laser confocal microscopy. The project training will also include writing reports of professional standards, and giving presentations in the group, leading the project.

这项研究将集中在钛合金标准牙种植体的工程抗感染和光活性涂层上。抗感染/光活性涂层将使用氟磷灰石矿物设计。涂层将使用旋涂和激光烧结进行。植入物的性能将通过硬度测量、FTIR、拉曼、紫外可见、光致发光、氧合血红蛋白和脱氧血红蛋白的特性测量来表征。涂层植入物将在成骨细胞、内皮细胞培养中进行测试，并与厌氧/好氧细菌共培养，以原位鉴定活性蛋白。材料的表征将使用X射线衍射、透射电子显微镜/扫描电子显微镜和激光共聚焦显微镜进行。项目培训还将包括撰写专业标准报告，并在小组中发表演讲，领导项目。