ACTG A5142:COMPARISON OF TREATMENT FOR INITIAL THERAPY OF HIV INFECTION

ACTG A5142：HIV 感染初始治疗的比较

• 批准号: 7202711
• 负责人: ROBERT C KALAYJIAN
• 金额: $ 0.58万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7202711
• 关键词: clinical research; human subject

DESCRIPTION: (provided by applicant) The purpose of this application to seek funding for the renewal of the General Clinical Research Center (GCRC) at Case Western Reserve University (CWRU) School of Medicine. The main GCRC is located at University Hospitals of Cleveland with a satellite at MetroHealth Medical Center (MHMC). In 2002, the GCRC supported 166 protocols for 90 principal investigators representing multiple schools, departments and divisions of CWRU, the Department of Cell Biology at the Cleveland Clinic Foundation, and the Department of Nutrition and Exercise Physiology at Cleveland State University. As a research institute, CWRU's School of Medicine has maintained a tradition of national leadership, including claim to 12 Nobel laureates among its alumni (5) and faculty (7). There are 1,493 full time faculty in the medical school. In 2001, CWRU researchers were funded over $174,000,000 by NIH. These awards include major funding for research in cancer, AIDS, diabetes, cystic fibrosis, hypertension, TB, skin diseases, Alzheimer's disease, cartilage regeneration, airway diseases, neonatal and adult metabolism, functional electric stimulation, perinatal medicine, and genetics defects of various types among others. Fifty-seven CWRU researchers were awarded more than $1 million in NIH support in 2002. In 2002, CWRU ranked 16th among the nations 126 medical schools in NIH support. Fifteen of the school's departments ranked in the top 20 of the corresponding departments. Compared to the last five year renewal, there has been a 17% increase in the number of GCRC investigators and 81% increase in number of protocols utilizing the GCRC which resulted in a 97% increase in the number of publications (from 201). The major areas of research include: 1. Biochemical and molecular enhancement of cancer chemotherapy. 2. Electronic restoration of movement in spinal cord injury and stroke. 3. Molecular biology and treatment of cystic fibrosis. 4. Carbohydrate and protein metabolism in pregnancy. 5. Epidemiology, genetics, and pathophysiology of sleep-disordered breathing. 6. Pathophysiology and renal outcomes of human hypertension. 7. Factors affecting feto-placental growth and development. 8. Pathophysiology and treatment of HIV diseases.

产品说明：（由申请人提供）本申请旨在为凯斯西储大学（CWRU）医学院的综合临床研究中心（GCRC）的更新寻求资金。主要的GCRC位于克利夫兰大学医院，卫星位于MetroHealth医疗中心（MHMC）。2002年，GCRC为90名主要研究人员提供了166项方案，这些研究人员代表CWRU的多个学校、部门和部门，克利夫兰临床基金会的细胞生物学系，以及营养和 克利夫兰州立大学运动生理学。作为一个研究机构，CWRU医学院保持了国家领导力的传统，其中校友（5）和教职员工（7）中有12名诺贝尔奖获得者。医学院有1，493名全职教师。2001年，CWRU研究人员获得了NIH超过1.74亿美元的资助。这些奖项包括对癌症、艾滋病、糖尿病、囊性纤维化、高血压、结核病、皮肤病、阿尔茨海默病、软骨再生、气道疾病、新生儿和成人代谢、功能性电刺激、围产期医学和各种类型的遗传缺陷等研究的主要资助。2002年，57名CWRU研究人员获得了超过100万美元的NIH支持。2002年，CWRU在NIH支持的全国126所医学院中排名第16位。该校有15个院系排名在相应院系的前20名。与上一次五年更新相比，GCRC研究者数量增加了17%，使用GCRC的方案数量增加了81%，导致出版物数量增加了97%（从201篇）。主要研究领域包括：1.癌症化疗的生化和分子增强。2.脊髓损伤和中风运动的电子恢复。3.囊性纤维化的分子生物学和治疗。4.妊娠期碳水化合物和蛋白质代谢。5.睡眠呼吸障碍的流行病学、遗传学和病理生理学。6.人类高血压的病理生理学和肾脏结局。7.影响胎儿胎盘生长发育的因素。8.艾滋病的病理生理学和治疗。