Improving outcomes in opiate dependence by understanding barriers and facilitators to opiate detoxification.

2021年，英国大约一半的药物中毒死亡与鸦片有关，这是有记录以来的最高数字。随着类鸦片完全戒毒（即减少剂量和停止使用）的减少，迫切需要新的药物来支持戒断。这一领域的研究资金不足且被忽视。帝国理工学院的成瘾小组是英国唯一一个研究治疗阿片类药物依赖的新药理学靶点的小组。forward研究旨在调查巴氯芬支持美沙酮解毒的安全性和有效性。为了了解和优化新疗法的实施，首先要了解为什么完成戒毒的人数在下降，参与者恢复的动机，以及戒断的潜在障碍。我的项目旨在确定阿片类药物成瘾治疗的关键促进因素和障碍。它将采用混合方法，分析来自问卷调查、半结构化访谈和当前文献的数据。它希望这项研究能够提供一个理解，为什么完成排毒的人数在下降，以及我们可以做些什么来支持那些希望排毒的人，或者那些通过戒烟可以改善健康的人。研究结果将通过帮助解释疗效数据为试验增加巨大的价值，并可以嵌入到未来的临床和研究实践中。

In 2021, approximately half of all drug poisoningmortalities in England involved an opiate, the highestnumber since records began. With a decline in completedopioid detoxes (i.e. dose reduction and cessation of use),the need for new medications to support abstinence isurgent. Research in this area is underfunded and neglected.The addiction team at Imperial College is the only group inthe UK conducting research into new pharmacologicaltargets for the treatment of opioid dependence. TheFORWARDS study aims to investigate the safety andefficacy of baclofen to support detoxification frommethadone. To inform and optimise the implementation ofnovel treatments, it is crucial to first understand why thenumber of completed detoxes is declining, participantmotivations for recovery, and potential barriers toabstinence.My project aims to identify key facilitators and barriers tothe treatment of opioid addiction. It would use a mixedmethodapproach, analysing data from questionnaires,semi-structured interviews, and current literature. It ishoped the study would offer an understanding as to whythe number of completed detoxes is declining, and whatcan be done to support those wishing to detox or whosehealth may improve if abstinent. Findings would add hugevalue to the trial by aiding the interpretation of efficacydata, and can be embedded into future clinical and researchpractice.