Cytokines and angiotensin II-induced hypertension

细胞因子和血管紧张素 II 诱导的高血压

• 批准号: 7060929
• 负责人: R Clinton Webb
• 金额: $ 213.58万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7060929
• 关键词: angiotensin /renin /aldosterone hypertension; angiotensin II; cytokine; pathologic process

DESCRIPTION (provided by applicant): Hypertension is a complex disease process involving many pathophysiological changes. In this program project, the individual research topics focus on the theme that cytokines contribute to abnormal blood pressure regulation in angiotensin II-induced hypertension. The strategy of the group is to monitor many relevant variables during the development of hypertension with the goal of defining the complete sequence of events from the introduction of an intervention (angiotensin II or cage switch stress) to the resultant elevation in blood pressure. Among these variables are alterations in neural and endocrine factors, cellular events and molecular and gene characteristics. Five principal investigators from two administrative units have joined to study these changes. Animal models will include mice and rats (experimental hypertension and genetically modified). Among the specific variables measured will be the following: mRNA for specific proteins, enzyme activities, genetic associations, vascular reactivity, blood pressure, hormone levels, endothelium-derived products, cytokines, calcium, reactive oxygen species and arachidonic acid metabolites. Research strategies will utilize the professional expertise and equipment described in two of the core units (Core A, Animal and Core B, Biochemistry). Biostatistical support and scientific management will be coordinated through the Administrative Unit. From these integrated projects, a better understanding of the factors contributing to hypertension will emerge.

描述（由申请人提供）：