Effect of NSAIDs on risk of Incident Lung Cancer: a cohort study

非甾体抗炎药对肺癌发生风险的影响：一项队列研究

• 批准号: 7330010
• 负责人: Christopher G. Slatore
• 金额: $ 5.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7330010
• 关键词: Affinity; Anti-Inflammatory Agents; Anti-inflammatory; Categories; Cohort Studies; Drug usage; Enzymes; Exposure to; Incidence; Investigation; Malignant neoplasm of lung; Morbidity - disease rate; Non-Small-Cell Lung Carcinoma; PTGS2 gene; Pathogenesis; Pathway interactions; Pharmaceutical Preparations; Population; Prevention; Public Health; Relative (related person); Risk; Role; Subgroup; base; cancer risk; cohort; hazard; interest; mortality

DESCRIPTION (provided by applicant): Lung cancer is a huge public health problem, both in terms of morbidity and mortality. No effective prevention or reduction strategy has been found despite a wealth of investigation. Non-steroidal anti- inflammatory drugs (NSAIDs) have been associated with a decreased risk of incident lung cancer. However, this association has not been confirmed and many previous trials have had important limitations. Furthermore, the effects of NSAIDs in relation to their specific COX-2 inhibition, the mechanism felt to be crucial for lung cancer pathogenensis, has not been explored. This project will attempt to answer the former question more rigorously and investigate the specific role of COX-2 blockade in lung cancer risk. We propose to use a large, population-based, cohort to examine the relationship between NSAID use and lung cancer incidence. Cox proportional hazards analysis will be performed on the exposure variables of interest, namely categories of NSAID use based on duration and intensity, after controlling for multiple confounders. Subgroup analyses will be performed according to the type of lung cancer as well as the differential selectivity of NSAIDs on the COX-2 enzyme. The results of this study will provide extremely useful information regarding possible chemopreventative effects of NSAIDs as well as elucidate possible underlying biologic pathways in lung cancer pathogenesis.

描述(申请人提供)：肺癌在发病率和死亡率方面都是一个巨大的公共卫生问题。尽管进行了大量调查，但没有找到有效的预防或减少战略。非类固醇抗炎药(NSAIDs)与降低肺癌发病风险有关。然而，这种联系还没有得到证实，之前的许多试验都有重要的局限性。此外，NSAIDs与其特异性COX-2抑制有关的作用尚未被探索，而COX-2被认为是肺癌发病的关键机制。该项目将试图更严格地回答前面的问题，并调查COX-2阻断在肺癌风险中的具体作用。我们建议使用一个基于人群的大型队列来研究非类固醇抗炎药的使用和肺癌发病率之间的关系。在控制了多个混杂因素后，将对感兴趣的暴露变量进行COX比例风险分析，即基于持续时间和强度的非类固醇使用类别。亚组分析将根据肺癌的类型以及非类固醇抗炎药对COX-2酶的不同选择性进行。这项研究的结果将为NSAIDs可能的化学预防作用提供极其有用的信息，并阐明肺癌发病机制中可能的潜在生物学途径。