Investigating the neural code for single-word reading

研究单字阅读的神经编码

• 批准号: 7222975
• 负责人: Laurie S Glezer
• 金额: $ 2.81万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-29 至 2010-01-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7222975
• 关键词: Accounting; Acquired Dyslexia; Address; Adult; Affect; Area; Attention; Behavioral; Brain; Brain Injuries; Brain imaging; Clinical; Code; Conflict (Psychology); Conscious; Data; Detection; Development; Diagnosis; Dyslexia; Frequencies; Functional Magnetic Resonance Imaging; Fusiform gyrus; Future; Glean; Goals; Image; Individual; Left; Letters; Life; Location; Masks; Modeling; Nature; Neurons; Orthography; Performance; Population; Printing; Process; Property; Public Health; Published Comment; Reading; Reading Disabilities; Reading Disorder; Recovery; Reporting; Research; Role; Shapes; Signal Transduction; Specificity; Staging; Stimulus; Techniques; Testing; Thinking; Visual; Visual Cortex; Visual Perception; Visual system structure; Work; Writing; abstracting; attentional modulation; base; blood oxygenation level dependent response; density; design; experience; extrastriate visual cortex; feeding; hemodynamics; innovation; insight; interest; literate; neuromechanism; novel; object recognition; prevent; relating to nervous system; research study; response; size; skills; statistics; stimulus processing; theories; visual process; visual processing

DESCRIPTION (provided by applicant): Successful reading requires the brain to correctly recognize printed individual words. It has been proposed that single-word reading can be viewed as a special case of visual object recognition with its dual goals of achieving specificity and invariance. This hypothesis allows us to leverage theories of object recognition to provide hypotheses for the neural bases of single-word reading, in particular the nature of the representation of visual words, how this representation is shaped by expertise, and is modulated dynamically by attentional effects. The specific aims of this proposal are to a) determine the impact of top-down attentional factors on single-word reading related activation, b) probe the selectivity of neurons in the VWFA and c) determine how word frequency affects the neural representation in the VWFA. To disentangle feed forward and top-down attentional components, we will use the masked priming technique, which has been widely utilized to examine single word reading. In this paradigm subjects are not consciously aware of the prime yet numerous behavioral studies show priming effects. We will combine this behavioral technique with functional MRI. Imaging studies of masked words show neuronal activation that is isolated mostly to visual areas indicating that subjects do perceive the stimuli. However, only so much can be gleaned from the BOLD response. Recently, a technique called repetition adaptation has been used to study neuronal tuning. Studies show that the repetition of a stimulus will result in reduced activation, which is thought to reflect a population of neurons specialized to process that stimulus. Recovery from adaptation corresponds to a change in the population of neurons processing the stimuli. Strong preliminary data suggest that this effect will not only allow us to probe neuronal tuning more directly, but also provide a better mechanistic model of how performance in reading tasks is based on neuronal tuning properties. The technique proposed in this project provides an innovative way to examine the neural correlates of single word reading in the occipitotemporal cortex. The relevance of this work for public health lies in its direct applicability to the study of reading disorders, whose underlying neural causes are still poorly understood. For instance, people with dyslexia often show altered reading-related activation in occipitotemporal cortex. The proposed project's aim to use advanced brain imaging and parameterized behavioral techniques to more directly probe the neuronal bases of activation in this area will provide a framework that in a next step can be applied to examine disordered reading, eventually leading to better detection, diagnosis, and treatment of reading disabilities.

描述（由申请人提供）：成功的阅读需要大脑正确识别印刷的单个单词。已有研究认为，单字词阅读可以看作是视觉物体识别的一种特殊情况，具有实现特异性和不变性的双重目标。这一假设使我们能够利用物体识别的理论，提供假设的神经基础的单个单词的阅读，特别是视觉词汇的表征的性质，这种表示是如何形成的专业知识，并动态调制的注意力的影响。本研究的具体目标是：a）确定自上而下的注意因素对单字阅读相关激活的影响; B）探测VWFA中神经元的选择性; c）确定词频如何影响VWFA中的神经表征。为了解开前馈和自上而下的注意成分，我们将使用掩蔽启动技术，这已被广泛用于检查单个单词的阅读。在这种范式中，被试并没有意识到启动，但大量的行为研究表明启动效应。我们将联合收割机与功能性磁共振成像技术相结合。对掩蔽词的成像研究显示，神经元激活主要集中在视觉区域，这表明受试者确实感知到了刺激。然而，从大胆的回应中只能收集到这么多。最近，一种称为重复适应的技术被用于研究神经元调谐。研究表明，刺激的重复会导致激活减少，这被认为反映了专门处理该刺激的神经元群体。从适应中恢复对应于处理刺激的神经元群体的变化。强有力的初步数据表明，这种效应不仅使我们能够更直接地探测神经元调谐，而且还提供了一个更好的机制模型，说明阅读任务中的表现如何基于神经元调谐特性。本研究提出的技术提供了一种新颖的方法来研究单个单词阅读在枕颞叶皮层的神经相关性。这项工作与公共卫生的相关性在于它直接适用于阅读障碍的研究，其潜在的神经原因仍然知之甚少。例如，患有阅读障碍的人经常表现出枕颞叶皮层与阅读相关的激活改变。拟议项目的目的是使用先进的脑成像和参数化的行为技术，更直接地探测在这一领域的激活的神经元基础将提供一个框架，在下一步可以应用于检查紊乱的阅读，最终导致更好的检测，诊断和治疗阅读障碍。