Patient-Oriented Research in Skin Diseases

描述（由申请人提供）： 该提案是Mary-Margaret Chren医学博士在皮肤病患者导向研究中的医疗保险研究者奖的申请。Chren博士是一位内科医生、皮肤科医生和临床流行病学家，目前是加州大学弗朗西斯科分校（UCSF）的副教授。Chren博士的职业目标是（1）进行严格的以患者为基础的研究，以了解，测量和改善慢性病患者的健康，使用皮肤病作为影响健康的无数领域的条件的模型，和（2）使用她的研究作为一种媒介，以指导以患者为导向的皮肤病研究的开始调查人员。本申请的目的是增加Chren博士在这些领域的学术潜力和贡献。 该申请描述了一项研究计划，该计划将建立在Chren博士目前的研究基础上，并将研究治疗非黑色素瘤皮肤癌（NMSC）的过程，这是最常见的恶性肿瘤。具体来说，这项研究将遵循NMSC队列，这是一个由Chren博士在1999年和2000年收集的1500多名新诊断的NMSC患者组成的连续队列。收集了关于患者、肿瘤和治疗的大量基线数据。在治疗后5年确定肿瘤复发和皮肤相关生活质量，以比较主要类型治疗的有效性。 申请还描述了一个指导计划，为开始调查，有三个部分：教学课程，“动手”的研究经验，和职业发展。教学课程与加州大学旧金山分校的示范性临床研究培训计划相结合，包括通过K30奖项的临床研究培训课程。实际研究经验将通过直接与Chren博士及其同事在她建立的数据集（包括上述NMSC队列）和新收集的数据上工作来获得。指导计划，针对皮肤科住院医生，研究员，教师和医学生，可以量身定制的能力，学员致力于研究职业发展的时间。 研究计划和指导计划共同提供了一个五年战略，使Chren博士能够扩大她正在进行的研究范围，并正式制定明确的指导安排，以培养新的以患者为导向的皮肤病研究人员。

DESCRIPTION (provided by applicant): This proposal is an application for a Medicare Investigator Award in Patient-Oriented Research in Skin Diseases for Mary-Margaret Chren, MD. Dr. Chren is an internist, dermatologist, and clinical epidemiologist who is currently Associate Professor in Residence, University of California at San Francisco (UCSF). Dr. Chren's career aims are (1) to perform rigorous patient-based studies to understand, measure, and improve the health of patients with chronic diseases, using skin diseases as a model of conditions that affect myriad domains of health, and (2) to use her research as a medium to mentor beginning investigators in patient oriented research in skin diseases. The purpose of this application is to increase Dr. Chren's scholarly potential and contribution in each of these domains. The application describes a Research Plan that will build on Dr. Chren's current research and will examine the course of treated nonmelanoma skin cancer (NMSC), the most frequent malignancy. Specifically, the research will follow the NMSC Cohort, a consecutive cohort of over 1500 patients with newly diagnosed NMSC that Dr. Chren assembled in 1999 and 2000. Substantial baseline data about the patients, tumors, and treatments were collected. Tumor recurrence and skin-related quality of life will be determined at five years after therapy, to compare effectiveness of the major types of therapy. The application also describes a Mentoring Plan for beginning investigators that has three parts: didactic curricula, "hands-on" research experience, and career development. Didactic curricula are integrated with UCSF's exemplary clinical research training programs, including the Training in Clinical Research curriculum through the K30 award. Practical research experience will be obtained by working directly with Dr. Chren and her colleagues on datasets she has established (including the NMSC Cohort described above) and on newly collected data. The Mentoring Plan, aimed at dermatology residents, fellows, and faculty, and medical students, can be tailored to the capacity of mentees to commit time to research career development. Together, the Research Plan and the Mentoring Plan provide a five-year strategy that will permit Dr. Chren to broaden the scope of her on-going research as well as formalize an explicit mentoring arrangement for developing new patient-oriented investigators in skin diseases.