Patient-Oriented Research in Skin Diseases

描述(由申请人提供)： 这项提案是为医学博士玛丽·玛格丽特·克伦申请的以患者为中心的皮肤病研究中的医疗保险研究员奖。Chren博士是一名内科医生、皮肤科医生和临床流行病学家，目前是加州大学旧金山分校驻校副教授。Chren博士的职业目标是(1)进行严格的以患者为基础的研究，以了解、测量和改善慢性病患者的健康状况，将皮肤病作为影响多种健康领域的疾病的模型，(2)以她的研究为媒介，指导以患者为导向的皮肤病研究的初学者。这项申请的目的是增加克伦博士在这些领域的学术潜力和贡献。 该申请描述了一个研究计划，该计划将建立在Chren博士目前的研究基础上，并将检查非黑色素瘤皮肤癌(NMSC)的治疗过程，NMSC是最常见的恶性肿瘤。具体地说，这项研究将遵循NMSC队列，这是Chren博士在1999年和2000年收集的1500多名新诊断的NMSC患者的连续队列。收集了关于患者、肿瘤和治疗的大量基线数据。肿瘤复发和皮肤相关的生活质量将在治疗后五年进行测定，以比较主要治疗类型的疗效。 该应用程序还描述了一项针对初级调查人员的指导计划，该计划包括三个部分：授课课程、实践研究经验和职业发展。教学课程与加州大学旧金山分校的模范临床研究培训计划相结合，包括通过K30奖项进行的临床研究课程培训。实际研究经验将通过直接与Chren博士和她的同事在她建立的数据集(包括上述NMSC队列)和新收集的数据上进行合作来获得。该指导计划面向皮肤科住院医师、研究员、教职员工和医学生，可以根据受训者投入时间研究职业发展的能力进行量身定做。 研究计划和指导计划共同提供了一个五年战略，这将使Chren博士能够扩大她正在进行的研究的范围，并正式确定一个明确的指导安排，以开发新的面向患者的皮肤病研究人员。

DESCRIPTION (provided by applicant): This proposal is an application for a Medicare Investigator Award in Patient-Oriented Research in Skin Diseases for Mary-Margaret Chren, MD. Dr. Chren is an internist, dermatologist, and clinical epidemiologist who is currently Associate Professor in Residence, University of California at San Francisco (UCSF). Dr. Chren's career aims are (1) to perform rigorous patient-based studies to understand, measure, and improve the health of patients with chronic diseases, using skin diseases as a model of conditions that affect myriad domains of health, and (2) to use her research as a medium to mentor beginning investigators in patient oriented research in skin diseases. The purpose of this application is to increase Dr. Chren's scholarly potential and contribution in each of these domains. The application describes a Research Plan that will build on Dr. Chren's current research and will examine the course of treated nonmelanoma skin cancer (NMSC), the most frequent malignancy. Specifically, the research will follow the NMSC Cohort, a consecutive cohort of over 1500 patients with newly diagnosed NMSC that Dr. Chren assembled in 1999 and 2000. Substantial baseline data about the patients, tumors, and treatments were collected. Tumor recurrence and skin-related quality of life will be determined at five years after therapy, to compare effectiveness of the major types of therapy. The application also describes a Mentoring Plan for beginning investigators that has three parts: didactic curricula, "hands-on" research experience, and career development. Didactic curricula are integrated with UCSF's exemplary clinical research training programs, including the Training in Clinical Research curriculum through the K30 award. Practical research experience will be obtained by working directly with Dr. Chren and her colleagues on datasets she has established (including the NMSC Cohort described above) and on newly collected data. The Mentoring Plan, aimed at dermatology residents, fellows, and faculty, and medical students, can be tailored to the capacity of mentees to commit time to research career development. Together, the Research Plan and the Mentoring Plan provide a five-year strategy that will permit Dr. Chren to broaden the scope of her on-going research as well as formalize an explicit mentoring arrangement for developing new patient-oriented investigators in skin diseases.