Florida Alzheimer's Disease Research

描述（由申请人提供）：在佛罗里达估计有430，000名阿尔茨海默病患者，其中坦帕湾和迈阿密/戴德县地区有大量的、种族多样的和不断增长的患有这种疾病的人口。事实上，就人口而言，佛罗里达是美国第四大州，也是阿尔茨海默病患者总数第二大州。显然，佛罗里达将是一个理想的地方，网站的国家情报局资助的阿尔茨海默病研究中心（ADRC）。然而，没有这样的佛罗里达州的ADRC存在。因此，来自全州的一组研究人员和医生已经联合起来设计并寻求本申请中描述的佛罗里达ADRC（FADRC）的资金。拟议的FADRC的总体目标体现在三个项目中，其目的是： 1.通过确定临床、流行病学、影像学、神经心理学和生物学标志物的组合，更好地了解从正常到MCI再到AD的过渡过程，最好地识别那些将经历AD或其他痴呆疾病认知能力快速下降的个体。 2.研究认知康复干预MCI和早期AD患者并减缓其疾病进展的能力。 3.使用AD小鼠模型来确定环境丰富（包括认知康复）的哪些方面最能减缓或逆转认知障碍，并可能类似地应用于人类患者。 这些项目是相互支持和协同的，因为项目1中发现的标志物可用于衡量成功和/或区分项目2中的人群，而项目3中获得的模型结果可用于帮助决定哪种类型的干预措施可能在人类中最成功。这三个项目由5个核心支持-临床，数据管理，神经病理学，教育和小鼠行为和神经病理学。FADRC设计中固有的协同作用的最终结果可能是开发一种新的治疗干预，可以减缓疾病的临床进程。 为了帮助计划中的FADRC的发展、管理和财政支持，2002年，佛罗里达立法机构设立并资助了Johnnie B。伯德老年痴呆症中心和研究所在南佛罗里达大学校园。伯德研究所的资金和人员将用于补充国家投资局的赠款，这将有助于确保拟议的FADRC的成功。

DESCRIPTION (provided by applicant): There are an estimated 430,000 Alzheimer's disease patients in Florida, with the Tampa Bay and Miami/Dade County areas having a large, ethnically diverse and growing population with this illness. Indeed, Florida is the fourth largest state in the country in terms of population, and the second largest in total number of Alzheimer's disease patients. Clearly Florida would be ideal place to site an NIA-funded Alzheimer's disease Research Center (ADRC). Yet no such Florida-based ADRC exists. Therefore, a group of researcher s and physicians from across the state have joined together to design and seek funding for the Florida ADRC (FADRC) described in this application. The general goals of the proposed FADRC are represented by the three Projects which aim: 1. To better understand the process of transition from normal to MCI to AD by determining which combinations of clinical, epidemiologic, imaging, neuropsychological, and biological markers best identify individuals who will experience a rapid rate of cognitive decline toward AD or other dementing illnesses. 2. To investigate the ability of cognitive rehabilitation to intervene in and slow disease progression in MCI and early AD patients. 3. To use mouse models of AD to determine which aspects of environmental enrichment (including cognitive rehabilitation) best slow or reverse cognitive impairment and might be similarly applied to human patients. These projects are mutually supportive and synergistic because markers found in Project 1 can be used to measure success and/or to distinguish populations in Project 2, and model results obtained in Project 3 can be used to help decide which type of intervention may be most successful in humans. The three projects are supported by 5 Cores- Clinical, Data Management, Neuropathology, Education, and Mouse Behavior and Neuropathology. The end result of the synergy inherent in the design of the FADRC may be the development a novel therapeutic intervention that can slow the clinical course of the disease. To aid in the development, administration and financial support of the planned FADRC, in 2002, the Florida Legislature established and funded the Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute on the campus of the University of South Florida. Byrd Institute funds and personnel will be used to supplement the NIA grant in a State-Federal collaboration that will help assure the success of the proposed FADRC.