Diagnostic & targeting reagents for lung cancer
Diagnostic & targeting reagents for lung cancer
批准号:
7495880
负责人:
Kathlynn C Brown
金额:
$4.98万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-06-07 至 2009-04-30
关键词:
AffinityAnimal ModelBacteriophagesBindingBiochemicalBiological AssayBiological MarkersCancer cell lineCancerousCell Surface ReceptorsCell surfaceCellsClassificationClinicalDiagnosisDiagnosticDrug Delivery SystemsFutureGenerationsGoalsHumanImmunohistochemistryIn VitroLaboratoriesLibrariesLigandsLung NeoplasmsMalignant NeoplasmsMalignant neoplasm of lungMediatingMethodologyMethodsMutagenesisNormal tissue morphologyPatternPeptidesPhage DisplayPharmaceutical PreparationsReagentSpecificitySurfaceTechnologyTestingTherapeuticTissuesTranslatingUnited StatesWomanbasecancer cellcancer diagnosiscarcinogenesiscell typein vivoinsightmenneoplastic cellreceptorscaffoldsmall moleculetargeted deliverytumoruptake
中文摘要
肺癌是美国男性和女性最大的癌症杀手。Discoveryof
英文摘要
Lung cancer is the largest cancer killer of both men and women in the United States. Discoveryof
ligands specific to receptor(s) on a surface of a lung cancer cell will impact clinical issues including
functional diagnosis andcell-specific drug delivery. Our overall goal is to generate a panel of cell-
specific molecules that couldbe used to classify tumor types and then be exploited for targeted
delivery of therapeutics. Using phage display technologies, my laboratory has developed platform
methodologies to isolate peptides that bind to and mediate uptake into specific cells. We have
successfully identified cell-specific targeting peptides for 30 different cell types, including 7 cancer cell
lines. The isolated peptides display remarkable cell-specificities, even among similar cells, and are able
to discriminate between normal and cancerous cells as well as different lung tumor cells. This high
discriminating power suggests that peptides could be identified that selectively bind to differenttumor
types, even those with similar classifications. We propose to isolate cell-targeting peptides for 16
different lung cancer lines and then utilize these peptides as diagnostic and tumor specific delivery
reagents. These peptides will be assayed for affinity and cell-specificity. Efforts will be directed towards
translating the targeting phage into small molecule targeting reagents and these peptide scaffoldswill
be utilized to deliver therapeutics to tumor cells both in vitro and in vivo. The cell specificity
demonstrated by these peptides indicates that they are recognizing distinct cell surface receptors that
may be of clinical value as biomarkers for lung cancer. Thus, we will utilize the peptides to identify the
cellular these unique cellular features. We will then explore the expression patterns of the receptor on a
panel of human lung cancer tissues by immunohistochemistry and compare this with the expression
level in matched normal tissues. Achieving our goals will impact lung cancer diagnosis and treatment as
well as solving general challenges in the field of targeted drug delivery.
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会议论文
A Suite of Tumor Targeting Peptides for Personalized Therapy of Lung Cancer
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批准号:8909666
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项目类别:
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资助金额:$24.88万
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财政年份:2014
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负责人:Kathlynn C Brown
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依托单位:
Multi-Layered Valency: A Novel Design of Peptidic Imaging Agents for ??v??6
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批准号:8507549
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项目类别:
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资助金额:$33.74万
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财政年份:2012
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负责人:Kathlynn C Brown
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依托单位:
Multi-Layered Valency: A Novel Design of Peptidic Imaging Agents for ??v??6
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批准号:8956924
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项目类别:
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资助金额:$34.7万
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财政年份:2012
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负责人:Kathlynn C Brown
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依托单位:
A Suite of Tumor Targeting Peptides for Personalized Therapy of Lung Cancer
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批准号:8657925
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项目类别:
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资助金额:$11.59万
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财政年份:2012
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负责人:Kathlynn C Brown
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依托单位:
Multi-Layered Valency: A Novel Design of Peptidic Imaging Agents for ??v??6
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批准号:8337163
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项目类别:
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资助金额:$35.77万
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财政年份:2012
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负责人:Kathlynn C Brown
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依托单位:
A Suite of Tumor Targeting Peptides for Personalized Therapy of Lung Cancer
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批准号:8508211
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项目类别:
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资助金额:$31.01万
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财政年份:2012
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负责人:Kathlynn C Brown
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依托单位:
A High Throughput Diagnostic Assay for Lung Cancer
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批准号:6913043
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项目类别:
-
资助金额:$15.6万
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财政年份:2005
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负责人:Kathlynn C Brown
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依托单位:
A High Throughput Diagnostic Assay for Lung Cancer
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批准号:7067131
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项目类别:
-
资助金额:$15.23万
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财政年份:2005
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负责人:Kathlynn C Brown
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依托单位:
Diagnostic & targeting reagents for lung cancer
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批准号:7234354
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项目类别:
-
资助金额:$31.75万
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财政年份:2005
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负责人:Kathlynn C Brown
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依托单位:
Diagnostic & targeting reagents for lung cancer
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批准号:6983025
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项目类别:
-
资助金额:$36.32万
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财政年份:2005
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负责人:Kathlynn C Brown
-
依托单位:
Diagnostic & targeting reagents for lung cancer
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批准号:7617486
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项目类别:
-
资助金额:$6.44万
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财政年份:2005
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负责人:Kathlynn C Brown
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依托单位:
Diagnostic & targeting reagents for lung cancer
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批准号:7407447
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项目类别:
-
资助金额:$32.25万
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财政年份:2005
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负责人:Kathlynn C Brown
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依托单位:
Diagnostic & targeting reagents for lung cancer
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批准号:7074705
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项目类别:
-
资助金额:$32.57万
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财政年份:2005
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负责人:Kathlynn C Brown
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依托单位:
Chemical & Biological Approaches for Cell Targeting
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批准号:6640322
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项目类别:
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资助金额:$39.0万
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财政年份:2002
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负责人:Kathlynn C Brown
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依托单位:
Chemical & Biological Approaches for Cell Targeting
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批准号:6750037
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项目类别:
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资助金额:$39.0万
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财政年份:2002
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负责人:Kathlynn C Brown
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依托单位:
Chemical & Biological Approaches for Cell Targeting
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批准号:6544927
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项目类别:
-
资助金额:$37.24万
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财政年份:2002
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负责人:Kathlynn C Brown
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依托单位:
海外基金