Next Generation Bio-Orthogonal Ynamine Reagents for the Preparation of Antibody-Drug Conjugates

精确功能化小分子先导化合物的制备是药物发现管道的重要组成部分。然而，伴随发展的离散功能化生物偶联物还没有发展到一个相当的复杂水平。本研究的目的是发展一种新的生物正交标记方法，用于制备抗体-寡核苷酸生物偶联物。这项研究将涉及合成化学、化学生物探针设计和质谱组学技术。

The preparation of precisely functionalised small molecule lead compounds is essential part of the drug discovery pipeline. However, concomitant development of discretely functionalized bioconjugates have not developed to an equivalent level of sophistication. The objective of this studentship is to develop a new bio-orthogonal tagging methodology for the preparation of antibody-oligonucleotide bioconjugates. This studentship will involve a blend of synthetic chemistry, chemical biological probe design, and mass spectrometric -omics techniques.