FASEB Summer Conference on: The Biology of Calpains in Health and Disease

描述（由申请人提供）：FASEB计划于2007年7月召开一次题为“健康与疾病中的calpain生物学”的夏季会议。这是第四次以加利福尼亚为重点的会议，将在科罗拉多州斯诺马斯举行。正在向三个不同的NIH研究所申请资金，其中包括NIAMS作为主要机构，NHLBI和NIA作为共同赞助者。从这些研究所获得的资金将为会议提供部分支助。今年的会议将有两个主要重点；1)了解钙蛋白酶的生化特性，2)了解钙蛋白酶在各种疾病过程中的作用。会议安排了八个主题，包括1)钙蛋白酶结构和结构-功能关系，2)钙蛋白酶的生物化学，3)钙蛋白酶在癌症，细胞凋亡和细胞周期中的作用，3)钙蛋白酶和横纹肌疾病，4)钙蛋白酶和神经退行性疾病，5)细胞运动，信号传导和整合素，6)钙蛋白酶在衰老和疾病的调节，7)钙蛋白酶在心肌和缺血中的作用，8)钙蛋白酶在动物科学中的作用。Ernesto Carafoli博士将作为主讲人，他将在会议开幕当天介绍他在细胞钙调节方面的工作。Carafoli博士是钙调节方面的世界级专家，钙调节对钙蛋白酶的激活非常重要。关于钙痛的生物学会议与NIH高度相关，因为钙痛参与了正常和病理过程。管家蛋白的活动对所有组织中正常的蛋白质周转和细胞骨架蛋白和膜蛋白的加工都很重要。钙蛋白酶3和钙蛋白酶10的突变与衰弱性疾病（肌肉萎缩症和糖尿病）有关。自上次calpain会议以来已经过去了三年，在基因组学、结构激活和疾病中的作用方面取得了实质性进展。拟议的方案将为维持这一领域的势头提供论坛。

DESCRIPTION (provided by applicant): A FASEB summer conference is planned for July 2007 entitled "Biology of Calpains in Health and Disease". This is the fourth such meeting focusing on calpains and it will be held in Snowmass, Colorado. Funds are being requested from three different NIH institutes that include NIAMS as the primary and NHLBI and NIA as co-sponsors. Funds obtained from these institutes will provide partial support for the meeting. The meeting this year will have two main emphases; 1) understanding the biochemical properties of calpains and 2) understanding the role of calpains in various disease processes. Eight stimulating sessions are planned for the meeting including 1) Calpain Structure and Structure-Function Relationships, 2) Biochemistry of Calpains, 3) Calpains in Cancer, Apoptosis and the Cell Cycle, 3) Calpains and Striated Muscle Disease, 4) Calpains and Neurodegeneration, 5) Cell motility, Signaling and Integrins, 6) Calpains in the Modulation of Aging and Disease, 7) Calpains in Cardiac Muscle and Ischemia and 8) Calpains in Animal Science. Dr. Ernesto Carafoli will be the keynote speaker and he will present his work on calcium regulation in cells on the opening day of the meeting. Dr. Carafoli is a world expert in calcium regulation, an issue that is important for calpain activation. A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathological processes. The activities of the house-keeping calpains are important for normal protein turnover and processing of cytoskeletal and membrane proteins in all tissues. Mutations in calpains 3 and 10 have associations with debilitating diseases (muscular dystrophy and diabetes). Three years have passed since the last meeting on calpain and substantial progress on the genomics, structure activation and roles in disease have been made. The proposed program will provide the forum by which the momentum in this field may be maintained.