2007 Mechanisms of Membrane Transport Gordon Conference

描述（由申请人提供）：为2007年6月10日至15日在新罕布什尔州蒂尔顿蒂尔顿学校举行的题为“膜运输机制”的戈登研究会议请求资金支持。在过去的40年里，该会议每两年召开一次，主要关注与膜转运蛋白的机制方面相关的领域。在2007年，我们将继续强调通道和传输体的高分辨率结构所带来的显著进步和见解。我们还关注其他揭示膜蛋白结构和功能的方法的最新发现，包括核磁共振和单分子水平分析等领域。从这些工作中获得的见解现在可以对肾脏和胃肠道系统功能的核心机制，肌肉和神经兴奋性的基础，神经突触的信号传递和药物的挤压进行批判性评估。除了突出及时和重要的进展外，这次会议还将汇集来自广泛学科的科学家，促进否则难以建立的互动。这些领域包括生理学、药理学、生物化学、神经科学、细胞生物学、微生物学、生物物理学和光学等领域。该计划密切关注高分辨率现在可用（或很快将）或预先存在的结构已经成功地用于指导更复杂示例的工作的选定示例。会议将包括7个正式会议，其中包括24个主要讲座，每次30分钟，然后有足够的时间（15分钟）与听众进行重要对话。我们还在讲台上花时间（6个简短的演讲）来突出选定的海报演讲者的贡献，重点是学生，博士后研究员和年轻研究者的新发现。此外，我们将留出时间公开讨论更具争议性的专题问题。按照惯例，我们将鼓励所有与会者带来他们最新作品的海报；根据历史数据，这将允许两次海报会议（周一/周二和周三/周四），每次30-40张海报。我们有意识地选择了一些年轻的研究者来做初级讲座，并招募了一些以前没有参加过这次会议的演讲者。该计划仍然具有足够的灵活性，以利用具有重大影响的最新意外发现。

DESCRIPTION (provided by applicant): Funds are requested for support of the Gordon Research Conference entitled Mechanisms of Membrane Transport, to be held June 10-15, 2007, at Tilton School, Tilton, New Hampshire. This conference has met biannually for the past 40 years, largely focusing on areas related to the mechanistic aspects of membrane transport proteins. In 2007, we will continue to emphasize the striking advances and insights enabled by high-resolution structures of channels and transporters. We also focus on the most recent findings on other methods that reveal membrane protein structure and function, including areas such as NMR and analysis at the single-molecule level. Insights gained from such work now allows critical evaluation of mechanisms central to the functioning of renal and GI systems, the basis of excitability in muscle and nerve, signal transmission at nerve synapses, and extrusion of drugs. In addition to highlighting the timely and important advances, this conference will bring together scientists from a broad range of disciplines, promoting interactions that are otherwise difficult to establish. These fields include such areas as physiology, pharmacology, biochemistry, neuroscience, cell biology, microbiology, biophysics and optics. The program focuses closely on selected examples where high-resolution is now available (or soon will be) or where pre-existing structures have successfully been used to guide work in more complex examples. The conference will include 7 formal sessions that include 24 primary lectures, each of 30 minutes length, followed by sufficient time (15 minutes) for significant dialog with the audience. We are also devoting time on the podium (6 shorter presentations) to highlight the contributions of selected poster presenters, with an emphasis on new findings by students, postdoctoral fellows and young investigators. In addition, we are allowing time for open discussion of topical issues of a more controversial nature. As is our usual practice, we will encourage all attendees to bring posters of their latest work; based on historical data, this will allow for two poster sessions (Monday/Tuesday and Wednesday/Thursday) with 30-40 posters each. We have consciously selected a number of young investigators to present primary lectures, and have recruited a number of speakers who have not before attended this conference. Sufficient flexibility remains in the program to take advantage of late-breaking unanticipated findings with significant impact.