2007 Mechanisms of Membrane Transport Gordon Conference

描述(由申请者提供)：申请资助将于2007年6月10日至15日在新罕布夏州蒂尔顿的蒂尔顿学校举行的戈登研究会议，题为膜运输机制。在过去的40年里，这次会议每两年举行一次，主要集中在与膜运输蛋白的机械方面相关的领域。在2007年，我们将继续强调渠道和运输器的高分辨率结构带来的惊人进步和洞察力。我们还重点介绍了揭示膜蛋白结构和功能的其他方法的最新发现，包括核磁共振和单分子水平的分析。从这些工作中获得的见解现在可以对肾脏和胃肠道系统功能的核心机制、肌肉和神经兴奋性的基础、神经突触的信号传输以及药物的排泄进行关键评估。除了强调及时和重要的进展外，这次会议还将把来自广泛学科的科学家聚集在一起，促进本来难以建立的相互作用。这些领域包括生理学、药理学、生物化学、神经科学、细胞生物学、微生物学、生物物理学和光学。该计划密切关注选定的例子，其中高分辨率现在可用(或即将)，或预先存在的结构已被成功地用于指导更复杂的例子的工作。会议将包括7个正式会议，其中包括24个主要讲座，每次30分钟，随后有足够的时间(15分钟)与观众进行重要对话。我们还将在讲台上花费时间(6个较短的演讲)来强调选定的海报演讲者的贡献，重点是学生、博士后研究员和年轻研究人员的新发现。此外，我们还留出时间对更具争议性的议题进行公开讨论。按照我们的惯例，我们将鼓励所有与会者携带他们最新作品的海报；根据历史数据，这将允许两次海报会议(周一/周二和周三/周四)，每次30-40张海报。我们有意识地选拔了一批青年调查员来主讲，并招募了一批以前没有参加过这次会议的演讲者。该计划保留了足够的灵活性，以利用具有重大影响的最新意外发现。

DESCRIPTION (provided by applicant): Funds are requested for support of the Gordon Research Conference entitled Mechanisms of Membrane Transport, to be held June 10-15, 2007, at Tilton School, Tilton, New Hampshire. This conference has met biannually for the past 40 years, largely focusing on areas related to the mechanistic aspects of membrane transport proteins. In 2007, we will continue to emphasize the striking advances and insights enabled by high-resolution structures of channels and transporters. We also focus on the most recent findings on other methods that reveal membrane protein structure and function, including areas such as NMR and analysis at the single-molecule level. Insights gained from such work now allows critical evaluation of mechanisms central to the functioning of renal and GI systems, the basis of excitability in muscle and nerve, signal transmission at nerve synapses, and extrusion of drugs. In addition to highlighting the timely and important advances, this conference will bring together scientists from a broad range of disciplines, promoting interactions that are otherwise difficult to establish. These fields include such areas as physiology, pharmacology, biochemistry, neuroscience, cell biology, microbiology, biophysics and optics. The program focuses closely on selected examples where high-resolution is now available (or soon will be) or where pre-existing structures have successfully been used to guide work in more complex examples. The conference will include 7 formal sessions that include 24 primary lectures, each of 30 minutes length, followed by sufficient time (15 minutes) for significant dialog with the audience. We are also devoting time on the podium (6 shorter presentations) to highlight the contributions of selected poster presenters, with an emphasis on new findings by students, postdoctoral fellows and young investigators. In addition, we are allowing time for open discussion of topical issues of a more controversial nature. As is our usual practice, we will encourage all attendees to bring posters of their latest work; based on historical data, this will allow for two poster sessions (Monday/Tuesday and Wednesday/Thursday) with 30-40 posters each. We have consciously selected a number of young investigators to present primary lectures, and have recruited a number of speakers who have not before attended this conference. Sufficient flexibility remains in the program to take advantage of late-breaking unanticipated findings with significant impact.