South Eastern Region Lipid Conference 2006

描述（由申请人提供）： 本申请旨在为将于2006年11月1日至11月3日在北卡罗来纳州收银员高汉普顿酒店举行的东南地区脂质会议提供部分资金。这将是关于这个主题的第41届年会。这些资金将专门用于支持初级研究人员，博士后研究员和研究生的注册和差旅费，他们将参加会议并以受邀演讲，简短演讲或海报的形式展示他们的工作。这些资金还将用于支付与主要发言人有关的差旅费和与主办网站有关的费用。这个成功的和既定的会议的广泛目标是提供一个形式的审查和讨论的结构，功能和调节脂质的最新研究。脂质酶通过产生或调节生物活性脂质和脂质衍生产物在细胞调节的许多方面发挥核心作用。 比如说， 磷脂酶A产生脂肪酸和溶血磷脂。这些酶启动包括溶血磷脂酸和花生四烯酸的类花生酸代谢物的受体活性脂质的产生，并且在癌症和炎性疾病中具有良好的作用。磷脂酶C和D响应于细胞表面受体的激动剂活化而产生脂质第二信使，所述细胞表面受体调节与细胞生长、存活、运动性和囊泡运输的控制偶联的信号传导途径。会议还包括关于合成和降解鞘脂的酶的会谈，这些酶在细胞应激反应和凋亡中发挥作用，以及通过质谱分析脂质结构的会议。这次会议汇集了科学家，他们对这些酶有着共同的兴趣，这些酶在不同的学科中工作，包括生物物理学，结构，细胞和分子生物学。该会议有一个强大的记录，包括既定的研究人员作为主旨发言人的演讲，但主要集中在研究生和博士后研究员的演讲。因此，该会议不仅为促进该领域的合作和新进展提供了一个有效的论坛，而且也是年轻科学家的培训工具。该主题领域得到了NIH的大力支持，有400多个活跃的项目，在过去10年中，该领域每年产生超过2000篇同行评审的研究出版物。本提案所要求的资金将为支持这次会议作出宝贵贡献。

DESCRIPTION (provided by applicant): This application seeks partial funding for the South Eastern Region Lipid Conference to be held from November 1st-Novemeber 3rd 2006 at the High Hampton Inn, Cashiers, North Carolina. This will be the 41st annual conference on this subject. These funds will be used specifically to support the registration and travel expenses of junior investigators, postdoctoral fellows, and graduate students who will be attending the conference and presenting their work as invited presentations, short talks or posters. The funds will also be used for travel expenses related to the key note speakers and for fees related to hosting site. The broad goal of this successful and established conference is to provide a form for review and discussion of recent research on the structure, function, and regulation of lipids. Lipid enzymes play central roles in many aspects of cell regulation by producing or modulating bioactive lipids and lipid-derived products. For example, phospholipases A generate fatty acids and lysophospholipids. These enzymes initiate production of receptoractive lipids including lysophosphatidic acid and the eicosanoid metabolites of arachidonic acid and have well established roles in cancer and inflammatory diseases. Phospholipases C and D produce lipid second messengers in response to agonist activation of cell surface receptors regulating signaling pathways coupled to control of cell growth, survival, motility and vesicular transport. The conference also includes talks on enzymes that synthesise and degrade sphingolipids with roles in cellular stress responses and apoptosis as well as a session on analysis of lipid structures by mass spectrometry. This conference brings together scientists with a shared interest in these enzymes that are working in diverse disciplines including biophysics, structural, cell and molecular biology. The conference has a strong record of including presentations of established investigators as keynote speakers, but mainly focuses on presentations by graduate students and postdoctoral fellows. Thus, the conference not only provides an effective forum for promoting collaborations and new advances in the field, but also serves as a training tool for young scientists. The subject area is one that receives considerable support from the NIH with over 400 active projects and this field has generated >2000 peer reviewed research publications each year over the last 10 years. The funds requested in this proposal will make an invaluable contribution to the support of this conference.