Lymphocytes and the Immune System Molecular, Cellular and Interactive Mechanisms

淋巴细胞和免疫系统分子、细胞和相互作用机制

• 批准号: 7254925
• 负责人: Stephen Desiderio
• 金额: $ 1.1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7254925
• 关键词: Accounting; American; Antigen Receptors; Antigens; Apoptosis; Arizona; Autoimmunity; Biological; Biological Process; Biology; Cell Differentiation process; Cell Fate Control; Cell physiology; Cells; Cellular biology; Cytidine Deaminase; Development; Diagnostic; Disease; Effector Cell; Evaluation; Event; Funding; Future; Gene Expression; Gene Rearrangement; Generations; Genes; Genetic; Genome; Genome Stability; Health Hazards; Hematopoietic System; Homing; Human; Hypersensitivity; Immune; Immune response; Immune system; Immunity; Immunoglobulin Class Switching; Immunoglobulin Somatic Hypermutation; Infection; Lead; Link; Lymphocyte; Lymphocyte Activation; Malignant Neoplasms; Malignant lymphoid neoplasm; Mediating; Methods; Microscopy; Molecular; NF-kappa B; Numbers; Oncogenic; Oral; Organism; Organogenesis; Participant; Personal Satisfaction; Play; Prevention; Receptor Gene; Regulation; Regulator Genes; Regulatory Pathway; Research; Resort; Role; Scientist; Sentinel; Series; Signal Transduction; Societies; Stem cells; System; T-Cell Activation; T-Lymphocyte; Technology; Therapeutic Intervention; Thinking; Time; Tissue-Specific Gene Expression; V(D)J Recombination; abstracting; base; cell transformation; chemokine; cytokine; design; hazard; immune function; insight; leukemia/lymphoma; new technology; novel strategies; pathogen; posters; prognostic; programs; receptor; receptor expression; repaired; response; symposium; tool; tumorigenesis

This is an application for partial funding of a conference on Lymphocytes and the Immune System: Molecular, Cellular and Integrative Mechanisms. This conference will be held under the auspices of FASEB at the Omni Resort, Tuscon, AZ on July 9-14, 2005. This conference is the second in a new series of FASEB Summer Research Conferences and is based upon a growing recognition that the immune system serves as a paradigm for understanding diverse biological processes including the regulation of cell fates, programmed gene rearrangements, genome stability, receptor mediated cell signaling and oncogenesis. Molecular, cellular and genetic characterization of the lymphocytes can provide new insights eukaryotic biology. Our proposed meeting is designed to highlight new investigative approaches and their applications to the analysis of the immune system and lymphocytes. This type of forum will illuminate cell biological and gene regulatory pathways that enable immune cell generation and function. To introduce the versatility of these new approaches we have included speakers who are world leaders in developing and applying cutting edge experimental approaches to a variety of systems as well as internationally recognized speakers who have directly applied these methods to the immune system. Approximately 150 participants will be chosen from among scientists most likely to share new information and to contribute to stimulating exchanges of ideas. The major session topics will be: 1) specification of immune cell fates, 2) antigen receptor gene rearrangements and DMA repair, 3) gene expression and locus accessibility in the immune system, 4) NF-kappaB and links between the innate and humoral immune systems, 5) gene regulatory networks and immune cell differentiation, 6) lymphocyte survival and transformation, 7) B and T cell activation, 8) regulation of immune responses, 9) microenvironments and lympho-organogenesis. There will be oral presentations of selected abstracts and two poster sessions. This conference will provide a forum for dialogue between scientists employing a broad variety of investigative approaches. The meeting will produce a contemporary perspective and overview of the immune system as well as a critical review of the recent research and will permit evaluation of future research directions.

这是淋巴细胞和免疫系统会议部分资金的申请： 分子、细胞和整合机制。这次会议将于2005年7月9日至14日在亚利桑那州图森市的Omni度假村举行。本次会议是FASEB夏季研究会议新系列的第二次，并且基于越来越多的认识，即免疫系统作为理解不同生物过程的范例，包括细胞命运的调节，程序化基因重排，基因组稳定性，受体介导的细胞信号传导和肿瘤发生。 淋巴细胞的分子、细胞和遗传特性可以为真核生物学提供新的见解。我们提议的会议旨在突出新的研究方法及其在免疫系统和淋巴细胞分析中的应用。这种类型的论坛将阐明使免疫细胞产生和功能的细胞生物学和基因调节途径。为了介绍这些新方法的多功能性，我们邀请了在开发和应用尖端实验方法到各种系统方面的世界领导者，以及直接将这些方法应用于免疫系统的国际公认的演讲者。将选出约150名参与者 从最有可能分享新信息和促进思想交流的科学家中选出。会议的主要议题将是：1）免疫细胞命运的特化，2）抗原受体基因重排和DMA修复，3）免疫系统中的基因表达和基因座可及性，4）NF-κ B和先天免疫系统与体液免疫系统之间的联系，5）基因调控网络和免疫细胞分化，6）淋巴细胞存活和转化，7）B和T细胞活化，8）免疫调节 反应，9）微环境和淋巴器官发生。将口头介绍选定的摘要和两次海报会议。这次会议将为采用各种调查方法的科学家之间的对话提供一个论坛。会议将产生一个当代的观点和免疫系统的概述，以及最近的研究的批判性审查，并将允许评估未来的研究方向。