Signal Transduction within the Nucleus Gordon Conference

描述(由申请者提供)：本申请旨在为将于2007年3月25-30日在美国加利福尼亚州维努拉皇冠假日酒店举行的题为“核内信号转导”的Gordon研究会议寻求部分资金。我们于2005年2月举行了非常成功的首次会议，我们还寻求为我们将于2009年春季举行的第三次会议争取资金承诺。这次会议汇集了各种各样的研究人员，他们专注于了解信号通路如何参与核过程的调节。许多酶和大分子机器有助于复杂的解码设备组合，以确保有机体在不断变化的环境中生存。这次会议的独特之处在于，研究信号通路的研究人员和研究核功能的研究人员的工作已经融合在一起。我们在信号和核过程方面大大扩大了这一计划，远远超过了我们的首届会议，该会议侧重于激动剂诱导的核脂和碳水化合物代谢。这些程序包括核质信号，核脂信号，染色质结构和修饰，DNA损伤/修复途径，核组织和空间结构的作用，核膜的动力学，以及mRNA的剪接和输出。其中许多途径和过程与疾病过程的病理生理学有很好的联系，强调了它们与改善人类健康的关系。例如，DNA修复途径与癌症生物学的关系，以及椎板病与早衰(早衰症)的关系。我们预计，这将是一次杰出而独特的会议，为杰出的研究人员提供了交流的机会。所要求的资金对本次会议的支助将是无价的。

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research conference entitled "Signal Transduction within the Nucleus" to be held March 25-30, 2007 at the Crown Plaza Hotel, Venura CA, USA. Our highly successful inaugural meeting was held February, 2005 and we seek to also secure funding commitment for our third meeting to be held in Spring 2009. This conference brings together a wide variety of investigators focused on understanding how signaling pathways participate in the regulation of nuclear processes. Numerous enzymes and macromolecular machines contribute to the complex ensemble of decoding devices necessary to ensure an organism's survival in ever-changing environments. The uniqueness of this conference is the mixing of investigators studying signaling pathways with those studying nuclear function whose work has converged. We have significantly broadened this program with respect to both signaling and nuclear processes, well beyond our inaugural conference which focused on agonist-induced nuclear lipid and carbohydrate metabolism. This programs includes nucleo-cytoplasmic signaling, nuclear lipid signaling, chromatin structure and modifications, DNA damage/repair pathways, roles of nuclear organization and spatial architecture, dynamics of the nuclear envelope, and mRNA splicing and export. Many of these pathways and processes have well-established connections to the pathophysiology of disease processes, underscoring their relationship to improving human health. For example, the relationships of DNA repair pathways to cancer biology, and laminopathies to premature aging (progeria). We anticipate that this will be an outstanding and unique meeting that offers the opportunity of cross-fertilization among outstanding investigators. The requested funds will be invaluable to the support of this conference.