A Seven Tesla MRI System for Small Animals MRI/MRS

描述（由申请人提供）：我们建议购买一个新的7特斯拉超导磁体和梯度设置，以升级我们现有的小动物磁共振成像（MRI）和光谱（MRS）设施。我们目前的系统依赖于一个18岁的磁铁，该磁铁被NIH资助的7项赠款大量用于中风、肿瘤、脑出血和癫痫的小动物模型的生理测量。本申请的目的是购买和安装一个新的磁铁和梯度设置到我们目前的系统，使其达到目前的标准，使我们能够服务于我们目前的赠款，并保持作为一个实验室的竞争力。亨利福特卫生系统（HFHS）将支付与此系统升级相关的任何费用（总额为927,000美元）的剩余部分，超过共享仪器赠款（500,000美元）提供的资金。 NMR实验室是HFHS核心设施，自1986年以来一直是NIH/NINCDS卒中中心（NINCDS 1 PO-1 NS 23393）。从历史上看，该机构一直专注于脑缺血和中风。近年来，脑肿瘤在我们的时间承诺中获得了越来越多的重视。HFHS目前正在开展扩散张量成像、血管生理学、分子成像、各种器官系统中前体细胞的MR跟踪、脑出血和癫痫等方面的新举措。这些建议使我们得出结论，我们目前的系统将无法满足目前和稳步增长的各种类型的非侵入性小动物解剖和生理评估的需求，必须更换或升级。实现这一目标的最具成本效益的方法是更换磁铁和梯度装置。这项共享仪器赠款将部分提供资金，使目前的MRI/MRS系统达到目前的标准，HFHS提供其余的。

DESCRIPTION (provided by applicant): We propose to purchase a new 7 Tesla superconducting magnet and gradient set to upgrade our existing small animal magnetic resonance imaging (MRI) and spectroscopy (MRS) facilities. Our present system relies on a magnet that is 18 years old and is heavily used by 7 NIH-funded grants for physiological measurements in small animal models of stroke, tumor, intracerebral hemorrhage and epilepsy. The aim of the present request is to purchase and install a new magnet and gradient set onto our present system to bring it up to current standards so that we can serve our present grants and remain competitive as a laboratory. Henry Ford Health System (HFHS) will meet the remainder of any costs associated with this system upgrade (total $927,000) above the funds provided by the Shared Instrument Grant award ($500,000). The NMR laboratory is a HFHS Core Facility, and has been an NIH/NINCDS stroke center (NINCDS 1 PO-1 NS 23393) since 1986. Historically, this facility has been strongly focused on cerebral ischemia and stroke. In recent years, cerebral tumor has gained increasing importance in our time commitments. New initiatives in diffusion tensor imaging, vascular physiology, molecular imaging, MR tracking of precursor cells in a variety of organ systems, intracerebral hemorrhage and epilepsy are currently underway at HFHS. These proposals have led us to conclude that our present system will not be capable of meeting the present and steadily increasing demands for various types of noninvasive small-animal anatomical and physiological evaluations and must either be replaced or upgraded. The most cost effective way to accomplish this will be to replace the magnet and gradient set. This Shared Instrumentation Grant will partially supply the funds to bring the present MRI/MRS system up to current standards, with HFHS supplying the rest.