VisualSonics Vevo 770 Imaging System

描述(由申请人提供)：申请资金购买视觉超音速Vevo 770成像系统，为耶鲁大学医学院的研究人员提供最先进的鼠标超声和多普勒成像。Vevo 770系统为心脏、血管和器官的高分辨率超声成像提供了一种功能强大、成本效益高的方法。多普勒容量可以测量大血管血流，分析压力梯度，并确定瓣膜返流和心脏内分流。该系统还提供了一种非常独特的能力来执行小鼠胚胎成像，允许快速、廉价和非侵入性地评估发育异常。该仪器将大大增强耶鲁大学14名研究人员正在进行和计划中的研究工作的能力和能力，他们研究的是缺血性心脏病、心肌肥厚、血管生成、先天性心脏病和发育生物学的小鼠模型。该提案结合了一个在成人和儿科心血管医学、发育生物学、血管生物学和成像科学方面具有互补专业知识的多学科小组，并将为跨学科研究提供重要的催化剂。该系统将是对耶鲁大学已经在老鼠成像方面的重大投资的高度补充，包括2004年由NIH共享仪器赠款(S10 RR018039-01)资助的MicroSPECT系统。耶鲁大学医学院对心血管研究、血管生物学和遗传学/血管生物学有着浓厚的兴趣和专业知识，致力于进一步发展小动物成像。学校将在新建的Anlyan中心提供最先进的空间和成本分摊，以保证保持Visualsonics仪器以最高效率运行所需的服务合同和维护。这一应用的优势包括关键人员在老鼠成像、心脏生理学、胚胎分析方面的成熟专业知识，以及研究心血管疾病分子机制的创新项目，以及高度认可的成像科学专业知识。该仪器将对NIH资助的现有生物医学研究的这个多样化计划产生积极影响。利用小鼠模型进行研究对了解人类疾病的基本机制具有重要意义，对于开发预防或治疗成人和儿童心血管疾病的创新策略至关重要。成人心血管疾病是这个国家的主要死亡原因，先天性心脏病是导致儿童残疾和死亡的主要原因。

DESCRIPTION (provided by applicant): Funding is requested for the purchase of a Visual Sonics Vevo 770 Imaging System to provide investigators at the Yale University School of Medicine with state-of-the-art mouse ultrasound and Doppler imaging. The Vevo 770 system provides a powerful and cost-effective approach to high resolution cardiac, vascular, and organ mouse ultrasound imaging. Doppler capacity allows for measurement of large vessel blood flow, analysis of pressure gradients, and determination of valvular regurgitation and intra-cardiac shunts. The System also provides a very unique ability to perform mouse embryonic imaging, allowing rapid, inexpensive and non-invasive assessment of developmental abnormalities. The instrument will substantially enhance the capabilities and capacity of ongoing and planned research efforts on the part of 14 Yale investigators studying mouse models of ischemic heart disease, cardiac hypertrophy, angiogenesis, congenital heart disease and developmental biology. The proposal coalesces a multi-disciplinary group with complimentary expertise in adult and pediatric cardiovascular medicine, developmental biology, vascular biology, and imaging science and will also provide an important catalyst for inter- disciplinary research. The System will be a highly complementary addition to the significant investment in mouse imaging already present at Yale, including a microSPECT CT system, funded in 2004 by an NIH Shared Instrumentation Grant (S10 RR018039-01). With substantial interest and expertise in cardiovascular research, vascular biology and genetics/vascular biology, The Yale School of Medicine is deeply committed to further developing small animal imaging. The School will provide state-of-the-art space in the newly constructed Anlyan Center and cost-sharing to guarantee the service contracts and maintenance needed to keep the VisualSonics instrument operating at peak efficiency. Strengths of this application include the established expertise of key personnel in mouse imaging, cardiac physiology, embryonic analysis, as well as innovative programs studying molecular mechanisms of cardiovascular disease and highly recognized expertise in imaging science. The instrument would positively impact on this diverse program of existing NIH-funded biomedical research. Investigation using mouse models has significant relevance to understanding fundamental mechanisms of human disease and is critical to the development of innovative strategies to prevent or treat cardiovascular disease in both adults and children. Adult cardiovascular disease is the leading cause of death in this country and congenital heart disease a major cause of disability and death in children.