HIV PREVENTION TRIAL UNIT (HPTU)

HIV 预防试验中心 (HPTU)

• 批准号: 7288444
• 负责人: Irving F. Hoffman
• 金额: $ 30万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288444
• 关键词: AIDS; AIDS education /prevention; AIDS therapy; Commonwealth of Independent States; HIV infections; United States; antiAIDS agent; behavior therapy; behavioral /social science research tag; clinical research; clinical trials; cooperative study; human immunodeficiency virus 1; human subject; human therapy evaluation; medical outreach /case finding; patient oriented research

DESCRIPTION (adapted from applicant's abstract): This application proposes formation of a four-institution consortium, the Eastern Prevention Trials Unit (EPTU) consisting of Yale University School of Public Health (New Haven, CT), State University of New York/Downstate Medical Center (SUNY-DMC) (Brooklyn, NY), the Biomedical Center on AIDS/St. Petersburg State University (SPSU) (St. Petersburg, Russia) and the Center for AIDS Intervention Research (CAIR) at the Medical College of Wisconsin (MCW) (Milwaukee, WI). The investigators propose to enroll into HPTN protocols suitable individuals residing in Connecticut, Brooklyn and St. Petersburg, Russia. MCW will contribute expertise in community-based behavioral intervention studies to the EPTU, particularly in Russia. All four institutions have overlapping geographical and research interests in HIV prevention in the eastern US (ongoing joint studies) and Eastern Europe (AIDS International Training and Research Programs in Russia [Yale/MCW/SPSU] and Eastern Europe [SUNY-DMC]). The EPTU could contribute to the HPTN by: (1) identifying effective prevention strategies; and (2) facilitating their evaluation through the Unit's large international population capacity (population base of 6 million in Connecticut and Brooklyn and 6 million in St. Petersburg). Large segments of this population base have high HIV incidence rates driven by political, economic, social, and demographic instability. The application attributes four significant strengths to the proposed consortium. First, it could provide access to populations in which the HIV epidemic is still in its early phases (St. Petersburg) and in which the epidemic has matured (Brooklyn and Connecticut). Second, it has HIV prevention research management skills and on-site expertise needed to recruit and retain these populations in prevention intervention trials. Third, it has the national and international theoretical and practical scientific expertise to assist the HPTN in carrying out its extensive and complex mandate. Fourth, the EPTU has the capacity to expand to increase the number of high-risk or infected individuals for enrollment in larger prevention intervention studies. The Yale/MCW/SPSU St. Petersburg AITRPP has established linkage points with critical non-governmental organizations (NGOs) throughout Russia concerned about AIDS. The AITRP at SUNY-DMC has similar connections that can foster expansion to sites in Poland. Project SIDA in Kinshasa, Congo, is an additional possible collaborator that could be brought into the EPTU should HPTN supplemental funds become available at a later date.

描述（改编自申请人的摘要）：本申请提出 成立了一个由四个机构组成的联合体，即东部预防审判股 （EPTU）由耶鲁大学公共卫生学院（纽黑文，康涅狄格州）组成， 纽约州立大学/州下医疗中心（SUNY-DMC）（布鲁克林， 彼得堡州立大学艾滋病生物医学中心（SPSU）（圣彼得堡）。 俄罗斯彼得堡）和艾滋病干预研究中心（CAIR）在 威斯康星州医学院（MCW）（密尔沃基，WI）。 调查人员 建议将居住在以下地区的合适个人纳入HPTN方案 康涅狄格州，布鲁克林和俄罗斯的彼得堡。 MCW将贡献 向EPTU提供基于社区的行为干预研究方面的专业知识， 特别是在俄罗斯。 所有四个机构都有重叠的地理 美国东部艾滋病毒预防研究兴趣（正在进行的联合 研究）和东欧（艾滋病国际培训和研究方案 在俄罗斯[耶鲁/MCW/SPSU]和东欧[SUNY-DMC]）。 EPTU可以 通过以下方式为高预防技术网络做出贡献：（1）确定有效的预防战略; （2）通过该股的大型国际会议， 人口容量（康涅狄格州和布鲁克林的人口基数为600万 彼得堡有600万人）。 这一人口基础的大部分 艾滋病毒高发病率是由政治、经济、社会和 人口不稳定。 该应用程序将四个重要优势归因于所提议的 财团 首先，它可以为艾滋病毒感染者提供服务， 流行病仍处于早期阶段（彼得堡）， 流行病已经成熟（布鲁克林和康涅狄格州）。 第二，它有艾滋病病毒 征聘所需的预防、研究、管理技能和现场专门知识 并将这些人群保留在预防干预试验中。 三是 国家和国际理论和实践科学专门知识 协助HPTN执行其广泛而复杂的任务。 第四、 EPTU有能力扩大以增加高风险或 受感染的个体，以便在更大的预防干预研究中登记。 耶鲁/MCW/SPSU圣彼得堡AITRPP建立了联系点， 俄罗斯各地的重要非政府组织 关于艾滋病 SUNY-DMC的AITRP也有类似的联系， 扩展到波兰的研究中心。 刚果金沙萨的SIDA项目是一个 其他可能的合作者，可以带入EPTU应该 HPTN补充资金将在晚些时候提供。

项目成果

HIV prevalence, sociodemographic, and behavioral correlates and recruitment methods among injection drug users in St. Petersburg, Russia.

俄罗斯圣彼得堡注射吸毒者的艾滋病毒患病率、社会人口统计学和行为相关性以及招募方法。

• DOI: 10.1097/01.qai.0000220166.56866.22
• 发表时间: 2006
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Shaboltas,AllaV;Toussova,OlgaV;Hoffman,IrvingF;Heimer,Robert;Verevochkin,SergeiV;Ryder,RobertW;Khoshnood,Kaveh;Perdue,Tom;Masse,BenoitR;Kozlov,AndreiP
• 通讯作者: Kozlov,AndreiP