Mechanistic Investigations in Homogeneous Catalysis

均相催化机理研究

• 批准号: 2892843
• 金额: --
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2892843
• 关键词: Mechanistic; Investigations; Homogeneous; Catalysis

The production of important fine chemicals, such as pharmaceuticals, relies on the use of homogeneous catalysis. Many key transformations are performed with organometallic, molecular, transition metal complexes. In order to improve the sustainability of chemical synthesis, there is a need to develop new catalysts which can operate at low loadings. The stability of a catalyst is often the main barrier to a catalyst being used industrially, as poor stability requires high loadings of an expensive catalyst. Despite the importance of catalyst deactivation (i.e. the reason that high loadings are needed), this is an area of catalytic science that is not well studied. This project will investigate a number of valuable catalytic reactions (e.g. hydration of alkynes and alkenes, oxidation of alkenes) and will aim to develop an understanding of the factors that influence catalyst performance. Mechanistic studies will examine the influence of conditions and catalyst structure on product selectivity, reaction rate and catalyst stability. The successful candidate will be supervised by Dr Paul Dingwall and Dr Mark Muldoon who have the relevant expertise to support a student in this project area. During the PhD, the student will develop a range of skills and knowledge that will make them very employable. For example, the project will involve synthesis (e.g. of ligands and metal complexes) and analytical chemistry (e.g. GC, HPLC, IR, MS and NMR). During the project, the student will also develop other important transferable skills, such as problem solving, writing and presentation skills.

制药等重要精细化学品的生产依赖于均相催化的使用。许多关键的转变都是通过有机金属、分子、过渡金属络合物来实现的。为了提高化学合成的可持续性，有必要开发能够在低负载下运行的新型催化剂。催化剂的稳定性往往是催化剂工业化使用的主要障碍，因为稳定性差需要高负载昂贵的催化剂。尽管催化剂失活很重要(即需要高负载的原因)，但这是一个没有得到很好研究的催化科学领域。该项目将研究一些有价值的催化反应(例如，烯烃和烯烃的水合反应，烯烃的氧化反应)，并旨在加深对影响催化剂性能的因素的了解。机理研究将考察条件和催化剂结构对产物选择性、反应速率和催化剂稳定性的影响。成功的候选人将由保罗·丁沃尔博士和马克·马尔登博士监督，他们拥有支持该项目领域学生的相关专业知识。在博士期间，学生将发展一系列技能和知识，这将使他们非常有就业能力。例如，该项目将涉及合成(例如，配体和金属络合物)和分析化学(例如，GC、高效液相、IR、MS和核磁共振)。在项目期间，学生还将发展其他重要的可转移技能，如解决问题、写作和陈述技能。