Microevolution of Salmonella enterica serovar Typhimurium - molecular basis of emerging threats to human health

食源性细菌病原体的新菌株变体是如何以及为什么出现并取代先前存在的菌株的？这个问题的答案对于干预细菌病原体沙门氏菌在家畜和野生动物中的传播非常重要，这些动物是人类感染的宿主。学生将采用计算方法来识别新出现的沙门氏菌菌株和分子生物学，以了解微进化对与出现相关的关键特征的影响。

How and why do new strain variants of foodborne bacterial pathogens emerge and replace pre-existing strains? The answer to this question is important to intervening in the spread of the bacterial pathogen Salmonella within livestock and wild animals that are reservoirs of infection in people. The student will employ computational approaches to identify newly emerging strains of Salmonella and molecular biology to understand the consequences of microevolution on key characteristics associated with emergence.