Exploring Sustainable Antibacterial Solutions for Personal Hygiene Products

抗菌药物包括多肽及其衍生物、分子机制、细菌生长抑制的实时可视化方法、与细菌表面相互作用的分析测量、可用于工业应用的表面固定化方法、稳定性和迁移研究。本项目主要研究抗菌纤维和非织造材料在个人卫生用品中的应用机理。抗菌剂（AMA）可以是多肽，如聚赖氨酸、乳酸链球菌素和防御素或其衍生物，其作用方式从破坏微生物细胞膜到破坏代谢。植物来源的抗菌剂，如绿茶和维生素E，对推动协同作用也很有兴趣。由于AMA需要牢固地附着在纤维基板上，以提供持久的性能并最大限度地降低迁移风险，因此将开发和评估能够更好地固定的表面改性或接枝策略，以实现工业规模扩大的可行性。科学见解有望使公司拥有的新材料/技术开发成为可能。该项目还旨在创建和开发实时可视化/测量ama -细菌相互作用的新功能。为了支持婴儿/Fem护理业务的项目，需要考虑实际应用和老化条件。

Antimicrobial agents including peptides and derivatives, molecular mechanisms, real-time visualization methods of bacterial growth inhibition, analytical measurements of surface interactions with bacteria, surface immobilization approach that is practical for industrial application, stability, and migration studies. This project focuses on studying the mechanisms of antibacterial fibre and nonwoven materials for application in personal hygiene products. Antimicrobial agents (AMA) can be peptides such as polylysine, nisin and defensin or derivatives with mode of actions varying from microbial cell membrane disruption to metabolic disruption. Antimicrobials of plant origin like Green Tea and Vitamin E are also of great interest for driving the synergy. As AMA needs to be robustly attached on fibre substrates to deliver durable performance and minimize migration risk, surface modification or grafting strategies enabling better immobilisation will be developed and evaluated for industrial scale-up feasibility. The scientific insights are expected to enable new material/technology developments that are ownable to the company. The project also aims to create and develop novel capabilities for visualizing/measuring the AMA-bacteria interactions in real time. Real application and aging conditions need to be factored in for supporting the projects in Baby/Fem Care business.