fMRI of CBT and CM for Cocaine Dependence

可卡因依赖的 CBT 和 CM 的功能磁共振成像

• 批准号: 7127192
• 负责人: Marc N Potenza
• 金额: $ 36.3万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-29 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127192
• 关键词: behavior modification; behavior prediction; behavioral /social science research tag; bioimaging /biomedical imaging; cingulate gyrus; clinical research; cocaine; cognitive behavior therapy; craving; drug abuse therapy; drug addiction; functional magnetic resonance imaging; human subject; human therapy evaluation; neural information processing; neurophysiology; neuropsychology; patient oriented research; prefrontal lobe /cortex; reinforcer; visual stimulus

DESCRIPTION (provided by applicant): We aim to study the neural mechanisms of behavioral treatment of cocaine dependence. Although multiple behavioral treatments including cognitive behavioral therapy (CBT) and contingency management (CM) have been shown to be effective in the treatment of cocaine dependence and other addictive disorders, little is known regarding the brain changes underlying their mechanisms of action. We propose integrating functional magnetic resonance imaging (fMRI) measures into a NIDA-funded behavioral treatment trial of CBT and CM to investigate brain function before and after treatment. We propose using at study onset and following 12 weeks of treatment three imaging paradigms that assess cocaine craving, reward processing and cognitive control, respectively. We propose using similar measures in a non-addicted control grouped imaged twice twelve weeks apart as an important comparison group. We predict that prior to treatment, cocaine dependent subjects will differ from controls on these fMRI and cognitive measures. We also predict that cocaine dependent subjects will show changes in fMRI and cognitive/behavioral functioning following treatment, and that control subjects will not show similar changes when imaged 12 weeks apart. Neural predictors and correlates of effective behavioral treatment for cocaine dependence for CBT and CM will be explored as these would have significant potential for refining therapies, and targeting specific therapies to specific forms of cocaine dependence (e.g., those with specific neural activation patterns). Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders.

描述（由申请人提供）：我们旨在研究可卡因依赖性行为治疗的神经机制。尽管已证明包括认知行为疗法（CBT）和应急管理（CM）在内的多种行为治疗对可卡因依赖性和其他成瘾性疾病的治疗有效，但对于其作用机理的大脑变化，知之甚少。我们建议将功能磁共振成像（fMRI）措施整合到CBT和CM的NIDA资助的行为治疗试验中，以研究治疗前后的大脑功能。我们建议在研究开始时使用，在处理12周后，分别评估可卡因渴望，奖励加工和认知控制的三个成像范式。我们建议在不成熟的对照组中使用类似的措施成像，分组成像两倍，作为重要的比较组。我们预测，在治疗之前，可卡因依赖性受试者将与这些功能磁共振成像和认知措施的控制不同。我们还预测，可卡因依赖性受试者将显示fMRI和治疗后的认知/行为功能的变化，并且相距12周时，控制受试者不会显示出类似的变化。将探讨可卡因依赖性的有效行为治疗的神经预测因子和CM和CM的有效行为治疗的相关性，因为这些将具有精炼疗法的重要潜力，并将特定疗法靶向特定形式的可卡因依赖性（例如，具有特定神经激活模式的人）。该项目的成功完成将奠定可卡因依赖性和其他成瘾性疾病中未来研究（例如那些结合行为和药理治疗的组合）的基础。