Mapping the MTL Memory System in Schizophrenia

映射精神分裂症的 MTL 记忆系统

• 批准号: 7184368
• 负责人: Katherine L Narr
• 金额: $ 14.96万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7184368
• 关键词: Mapping; MTL; Memory; System; Schizophrenia

DESCRIPTION (provided by applicant): This career development plan will support the candidate's goals of mastering new imaging methodologies to investigate multiple aspects of a specific brain system in schizophrenia. This systems approach will allow a deeper understanding of the mechanisms associated with declarative memory (DM) impairments that are mediated by the medial temporal lobe (MTL) memory system (hippocampus, parahippocampal region and cerebral cortex). Guidance from accomplished investigators, state-of-the-art imaging facilities, and didactic training provide the infrastructure needed to achieve these goals. The rich institutional environment at UCLA further supports the candidate's long-term plan to develop a productive and independent program of research using imaging methods to better understand the pathophysiological underpinnings of brain disturbances in neuropsychiatric disorders. DM impairments and hippocampal volume reductions are shown particularly vulnerable to disease processes in schizophrenia and to indicate a genetic predisposition towards the illness. However, it is uncertain whether abnormalities of declarative memory (DM) reflect disturbances in regional brain activity and/or in functional connectivity and whether such impairments relate to structural abnormalities within this neural network. To address these questions, the candidate will combine structural, functional and diffusion tensor imaging to map structural and functional abnormalities of the MTL memory system in schizophrenia patients, first-degree relatives of patients and healthy comparison subjects recruited through a larger NIMH study, "Transmission of Vulnerability Factors for Schizophrenia." The research plan includes advanced structural image analysis techniques and functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) strategies that will be employed to dissociate the structural and functional correlates of MTL disturbances including declarative memory deficits in schizophrenia and to establish the presence of genetic liability effects.

描述（由申请人提供）：本职业发展计划将支持候选人掌握新成像方法的目标，以研究精神分裂症特定脑系统的多个方面。这种系统方法将使人们更深入地了解与内侧颞叶（MTL）内存系统（Hippocampus，parahampocampal区域和大脑皮层）介导的声明记忆（DM）损伤相关的机制。有成就的研究人员，最先进的成像设施和教学培训的指导提供了实现这些目标所需的基础设施。加州大学洛杉矶分校（UCLA）丰富的机构环境进一步支持了候选人的长期计划，该计划使用成像方法制定了一项富有成效的研究计划，以更好地了解神经精神疾病中脑部障碍的病理生理基础。 DM损伤和海马体积减少特别容易受到精神分裂症疾病过程的影响，并表明对疾病的遗传倾向。但是，尚不确定声明记忆（DM）的异常是否反映了区域大脑活动和/或功能连通性的干扰，以及这种障碍是否与该神经网络中的结构异常有关。为了解决这些问题，候选人将将结构，功能和扩散张量成像结合在一起，以绘制精神分裂症患者MTL记忆系统的结构和功能异常，患者的一级亲戚以及通过较大的NIMH研究招募的健康比较主题，“较大的NIMH研究，”精神分裂症的脆弱性因素的传播。该研究计划包括先进的结构图像分析技术和功能磁共振成像（FMRI）和扩散张量成像（DTI）策略，这些策略将被用于解散MTL干扰的结构和功能相关性，包括精神分裂症的声明性记忆缺陷，并在精神分裂症中建立遗传无效效应的存在。