Malarial Immunity in Pregnant Cameroonian Women

喀麦隆孕妇的疟疾免疫力

• 批准号: 7265640
• 负责人: Diane Wallace Taylor
• 金额: $ 60.47万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7265640
• 关键词: Malarial; Immunity; Pregnant; Cameroonian; Women

DESCRIPTION (provided by applicant): Project Summary: Plasmodium falciparum malaria is a major health problem for pregnant women since it increases maternal mortality and poor pregnancy outcomes. In addition, infants whose mothers have malaria during pregnancy are at an increased risk of developing severe malaria, anemia, asthma and dying during the first year of life than those whose mothers remain malaria-free. Our long-term goal is to improve the health of women and children living in sub-Saharan Africa. Accordingly, scientists at the University of Yaounde, Cameroon and University of Hawaii propose to answer key questions about the current recommended strategy for prevention of malaria during pregnancy, namely intermittent preventive treatment using sulfadoxine-pyrimethamine (IPT-SP). Specifically, we seek to determine if IPT-SP administered during the 2nd and/or 3rd trimester influences 1) the acquisition of antibodies (Ab) that inhibit parasite sequestration in the placenta, 2) placental pathology associated with low birthweight babies, 3) transplacental transfer of antimalarial IgG to vaccine-candidate antigens, 4) in utero priming of fetal T and B cells, and 5) the number and severity of P. falciparum infections infants have, as well as their rate of acquisition of immunity, during the first year of life. Studies will be conducted in the city of Yaounde where transmission is ~1 infectious bite per month and in rural villages where individuals receive ~0.7 infectious bites per night. The proposed studies will be the first to evaluate IPT-SP in pregnant women living in Central/West Africa and in an area where transmission of malaria is low. It will also be the first to study the effect of IPT-SP on production of Ab to the malaria antigen VAR2csa and how this relates to placental pathology associated with LEW babies. Finally, the study will be the first to determine if IPT-SP reduces the level of protective immunity infants have at birth and how this influences malaria episodes and Ab responses in infants during the 1st year of life. Relevance: The proposed study will help determine the strengths and weaknesses of the method currently recommended by the World Health Organization for prevention of malaria in pregnant women living in developing countries. New information from this study should lead to improved health care for African mothers and their children.

项目概述：恶性疟原虫疟疾是孕妇的一个主要健康问题，因为它增加了孕产妇死亡率和不良妊娠结局。此外，母亲在怀孕期间患有疟疾的婴儿在出生后第一年患严重疟疾、贫血、哮喘和死亡的风险比母亲没有患疟疾的婴儿更高。我们的长期目标是改善生活在撒哈拉以南非洲的妇女和儿童的健康。因此，喀麦隆雅温得大学和夏威夷大学的科学家建议回答关于目前建议的怀孕期间预防疟疾战略的关键问题，即使用磺胺嘧啶-乙胺嘧啶（IPT-SP）的间歇性预防性治疗。具体地，我们试图确定在妊娠中期和/或妊娠晚期施用的IPT-SP是否影响1）抑制胎盘中寄生虫隔离的抗体（Ab）的获得，2）与低出生体重婴儿相关的胎盘病理学，3）抗疟疾IgG向疫苗候选抗原的经胎盘转移，4）胎儿T和B细胞的子宫内引发，和5）婴儿在生命的第一年中感染恶性疟原虫的数量和严重程度，以及他们获得免疫力的比率。研究将在雅温得市进行，那里的传播为每月约1次感染性叮咬，在农村，那里的个人每晚约接受0.7次感染性叮咬。拟议的研究将是第一次评估生活在中非/西非和疟疾传播率低的地区的孕妇的IPT-SP。这也将是第一个研究IPT-SP对疟疾抗原VAR 2csa抗体产生的影响，以及这与LEW婴儿相关的胎盘病理学的关系。最后，该研究将首次确定IPT-SP是否会降低婴儿出生时的保护性免疫水平，以及这如何影响婴儿在出生后第一年的疟疾发作和抗体反应。相关性：拟议的研究将有助于确定世界卫生组织目前建议的用于预防发展中国家孕妇疟疾的方法的优缺点。这项研究的新信息应该会改善非洲母亲及其子女的医疗保健。