The effectiveness and safety of treating dentine hypersensitivity with bioactive glasses

生物活性玻璃治疗牙本质过敏的有效性和安全性

• 批准号: 2898082
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898082
• 关键词: effectiveness; safety; treating; dentine; hypersensitivity

Dentine hypersensitivity (DH) is a commonly occurring dental condition where sharp pain derived from exposed dentine in response to stimuli that cannot be ascribed to any other dental diseases. It is highly prevalent affecting up to 69% of the UK population and has a significant impact on the quality of life. Occlusion of open dentine tubules by brushing teeth with a desensitising toothpaste is a common but effective method that offers a quick alleviation of DH. Bioactive glasses that degrade in oral environment and precipitate apatite were thought to be beneficial, and have been introduced to toothpastes, e.g. Novamin (45S5 Bioglass) for Sensodyne by GSK, fluoride containing bioactive glass for BioMin F by BioMin Technologies Ltd. Apatite formation on top of open dentine tubules were evident by SEM and known to contribute towards long term pain relief.Although considerable effort has been spent on modelling apatite formation of bioactive glasses and the chemical dissolution of mineralised dental tissues including a recent outstanding 4D synchrotron X-ray tomography (xCT) study showing the capacity of monitoring changes in dentine tubule size and demineralisation depth. However, to date we have insufficient understanding of how bioactive glass particles within dentine tubules interact with tubule walls, how the open tubule size and occlusion depth by bioactive glasses change with time and how mineral density of peritubular and intertubular dentine change, the long-term safety of bioactive glass on dental pulp. Therefore, this project aims to 1) better understand the effectiveness of treating dentine hypersensitivity with bioactive glasses using X-ray tomography 2) evaluate the safety of bioactive glasses on dental pulp 3) ultimately develop a new intervention that not safely but also effectively treat dentine hypersensitivity for better Oral Health.

牙本质过敏症（DH）是一种常见的牙科疾病，其中暴露的牙本质对不能归因于任何其他牙科疾病的刺激产生尖锐疼痛。它非常普遍，影响了高达69%的英国人口，并对生活质量产生重大影响。通过使用脱敏牙膏刷牙堵塞开放的牙本质小管是一种常见但有效的方法，可以快速缓解DH。在口腔环境中降解并沉淀磷灰石的生物活性玻璃被认为是有益的，并已被引入牙膏中，例如Novamin（45S5生物玻璃），用于GSK的Sensodyne，BioMin Technologies Ltd.的BioMin F的含氟生物活性玻璃。通过SEM可以明显看出，在开放的牙本质小管顶部形成磷灰石，并且已知磷灰石有助于长期缓解疼痛。对生物活性玻璃的磷灰石形成和矿化牙齿组织的化学溶解进行建模，包括最近出色的4D同步加速器X射线断层扫描（xCT）研究，显示了监测牙本质小管尺寸和脱矿深度变化的能力。然而，到目前为止，我们对生物活性玻璃颗粒在牙本质小管内如何与小管壁相互作用，生物活性玻璃如何随时间改变开放小管的大小和封闭深度，以及管周和管间牙本质的矿物质密度如何变化，生物活性玻璃对牙髓的长期安全性了解不够。因此，本项目旨在1）使用X射线断层扫描更好地了解生物活性玻璃治疗牙本质过敏症的有效性2）评估生物活性玻璃对牙髓的安全性3）最终开发一种新的干预措施，虽然不安全，但也有效地治疗牙本质过敏症，以改善口腔健康。