Microfluidic redox sensor

微流控氧化还原传感器

• 批准号: 2898665
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898665
• 关键词: Microfluidic; redox; sensor

hiols are the organic compounds that contain a sulphydryl group. In the body, thiols constitute the major portion of the total body antioxidants and plays a significant role in defence against reactive oxygen species. Thiols also share significant roles in detoxification, signal transduction, apoptosis and various other functions at molecular level. Early studies show that the thiol status, including the redox state (ratio between the reduced and oxidized forms) could indicate the health of the body and with decreased levels linked to various medical disorders. Currently there are limited methods and technologies for detecting this redox state, even more difficult for monitoring in cells or in tissues in vivo. Furthermore, current methods are also limited by only providing a snapshot of the redox state so can provide only limited insight.

硫醇是含有巯基的有机化合物。在体内，硫醇构成了全身抗氧化剂的主要部分，在防御活性氧方面起着重要作用。巯基还在解毒、信号转导、凋亡等分子水平上发挥重要作用。早期的研究表明，硫醇状态，包括氧化还原状态（还原和氧化形式之间的比率）可以指示身体的健康状况，并且与各种医学疾病相关的水平降低。目前，用于检测这种氧化还原状态的方法和技术有限，甚至更难以在体内细胞或组织中监测。此外，目前的方法还受到仅提供氧化还原状态的快照的限制，因此只能提供有限的见解。