Discovery of New microbial consortia for the degradation and biovalorisation of Polypropylene

发现用于聚丙烯降解和生物价值的新微生物群落

• 批准号: 2898891
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2898891
• 关键词: Discovery; New; microbial; consortia; degradation

Background: Plastic waste is a huge problem facing society with around 361 million tonnes ofplastic produced per year globally. Much of this plastic is single use and not recycled and as suchends up contaminating the environment. Additionally, the production of plastics from fossil fuelshas an associated CO2 cost that fuels climate change. In recent years advances have been madeutilising microbial consortia or enzymatic methods to break down polymers, e.g. the discovery andengineering of PETases. However, many polymers such as polypropylene (PP) remain recalcitrantto a biologically based mechanism of breakdown. This is a key challenge, as PP accounts for 16% ofpolymer production annually. As well as being able to degrade plastics a range of microorganismscan act as a platform for the renewable, sustainable production of polyhydroxyalkanoates (PHA),that are used in biodegradable plastic production.The aim of the project is to discover and engineer biological systems to facilitate the breakdownof PP, with the potential to biovalorise it into PHAs. In this way PP could be converted to a feedstock for the microbial production of small molecule inputs for the sustainable, biodesignedproduction of biodegradable plastics.

背景：塑料废物是社会面临的一个巨大问题，全球每年生产约3.61亿吨塑料。这种塑料的大部分是一次使用，而不是回收的，因此污染了环境。此外，化石燃料SHA的塑料生产燃料气候变化的相关二氧化碳成本。近年来，已经取得了微生物联盟或酶促方法的进步，以分解聚合物，例如石4的发现和工程。然而，许多聚合物（例如聚丙烯（PP））仍然是基于生物学的分解机制的顽固性。这是一个关键的挑战，因为PP每年占聚合物的16％。除了能够降解塑料的一系列微生物扫描，是可再生，可持续生产的多羟基烷烃（PHA）的平台，这些平台用于生物降解的塑料生产中。该项目的目的是发现和工程生物系统，以促进PP，以促进PP，并促进生物销量的损坏，从而促进Phass It It the Phass，从而促进Phass It to phass逐渐变为Phas。以这种方式，PP可以转换为原料，以用于小分子输入的微生物产生，以实现可持续的生物降解塑料生产。