Impacts of Air Pollution from Ultrafine Tire-Wear Particles on Cardiorespiratory Health

超细轮胎磨损颗粒造成的空气污染对心肺健康的影响

基本信息

批准号：
2899750
负责人：
金额：
--
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2899750
关键词：
Impacts Air Pollution Ultrafine Tire

项目摘要

Due to reduction in engine emissions from vehicles, the relative contribution of tire-wear in total traffic related air pollution is increasing [1]. However, our understanding of the health effects of ultrafine tire particles is still limited. Light-duty tires are typically made up of synthetic rubber, derived from crude oil, rather than natural rubber. This increases the polycyclic aromatic hydrocarbon (PAH) component of tires, and the potential cardiotoxicity of tire-related particulate matter (PM) [2]. For this PhD CASE project, the student will work closely with our Industrial Partner, Emissions Analytics [3] who is global leader in independent testing of realworld emissions for passenger and commercial vehicles. Here the student will learn cutting-edge chemical analytics techniques and generate real-life tire-wear particles for use in their biomedical test systems. At the University of Manchester, the PhD candidate will investigate the impact of air pollution from tire-wear on human health using lung and cardiac in vitro assay systems focussing on each system independently as well as the interconnectivity between lung and heart systems. To relate findings from the in vitro systems studies to human population health, the project will finish with an epidemiological investigation which adapts current exposure models of PM pollution and health [4] to include PM from tire-wear.

由于车辆发动机排放的减少，轮胎磨损在总交通中的相对贡献正在增加[1]。但是，我们对超细轮胎颗粒的健康影响的理解仍然有限。轻型轮胎通常由源自原油而不是天然橡胶的合成橡胶组成。这增加了轮胎的多环芳烃（PAH）成分，以及轮胎相关颗粒物（PM）的潜在心脏毒性[2]。对于这个博士学位案件项目，该学生将与我们的工业合作伙伴，排放分析[3]密切合作，他是对乘客和商用车的现实世界排放独立测试的全球领导者。在这里，学生将学习最先进的化学分析技术，并生成现实生活中的轮胎磨损颗粒，以用于其生物医学测试系统。在曼彻斯特大学，博士候选人将使用肺和心脏的体外测定系统研究轮胎磨损对人类健康的影响，专注于每个系统，以及独立于每个系统，以及肺和心脏系统之间的互连性。为了将从体外系统研究与人口健康的发现联系起来，该项目将通过流行病学研究结束，该研究适应了当前的PM污染和健康暴露模型[4]，包括轮胎磨损中的PM。