Using the UWBCS to Assess Racial Disparities in Breast Cancer Incidence & Surviva

威斯康星州大学乳腺癌模拟（UWBCS）是由癌症干预和监测建模网络（CISNET）资助的多学科团队开发和验证的，并产生了与1975-2000年美国SEER计划公布的密切匹配的年龄和阶段特异性发病率和死亡率。UWBCS是一个系统分析，离散事件模拟的个体妇女纳入事件的肿瘤发病，肿瘤发现，乳腺癌筛查，乳腺癌治疗，以及死亡的乳腺癌或其他妇女年龄在20-100岁。我们将通过将种族纳入模型来增强UWBCS。然后，模拟将被应用于估计癌症控制干预措施对乳腺癌发病率，生存率和死亡率的影响，现有的筛查和治疗技术分别为非洲裔美国人和白色妇女。这项分析将帮助我们解决非洲裔美国人和白色妇女在乳腺癌生存率和死亡率方面日益扩大的差距。UWBCS的持续增强和应用将解决我们对乳腺癌控制措施的理解方面的差距，这是其他方法（如随机试验）无法解决的。这项研究的公共卫生拟议的研究将帮助我们确定不同的影响，乳腺癌的发病率和死亡率的筛查和治疗的改善，非洲裔美国人和白色妇女在美国人口之间的1975年和2000年，这将是有用的所有政策制定者，研究界，医疗保健专业人员和他们的组织，信息和宣传组织。这些变化的结果可能有助于政策制定者和癌症社区采取措施缩小不同种族之间的生存和死亡率差距，这对改善公共卫生非常重要。

The University of Wisconsin Breast Cancer Simulation (UWBCS) was developed and validated by a multidisciplinary team with Cancer Intervention and Surveillance Modeling Network (CISNET) funding and produces age- and stage-specific incidence and mortality rates that closely match those published by the SEER program for the US during 1975-2000. The UWBCS is a systems analytic, discrete-event simulation of individual women incorporating events for tumor onset, tumor discovery, breast cancer screening, breast cancer treatment, and death from either breast cancer or other women aged 20-100 years. We will enhance the UWBCS by incorporating race into the model. The simulation will then be applied to estimate the impact of cancer control interventions on breast cancer incidence, survival, and mortality rates of existing screening and treatment technologies separately for African-American and white women. This analysis will help us address the widening disparity between African American and white women in breast cancer survival and mortality. Continuing enhancement and application of the UWBCS will address gaps in our understanding of breast cancer control measures that other approaches, such as randomized trials, can not. of this research to Public Health The proposed research will help us identify the differential impacts on breast cancer incidence and mortality of screening and treatment improvements for African American and white women in the US population between 1975 and 2000, which will be useful to all policy makers, research community, healthcare professionals and their organizations, information and advocacy organizations. The results of these changes may help policy makers and cancer community to take the steps to lower the gaps in survival and mortality between various races, which is very significant in improving public health.